Identification in silico of antimicrobial sequences of rainbow trout brain proteins in the context of integrated in the context of complex recycling of aquaculture wastes

Aquaculture is one of the main suppliers of fishery products and maintain its sustainable growth in the world, exceeding industrial fishing. At the same time, the problem of integrated processing of aquaculture by-products is on the environmental and production agenda. Fish processing by-products, which remains after obtaining the target product (fillet, offal, etc.), can be a “supplier” of valuable biological components. In particular, fish express antimicrobial peptides that exhibit broad-spectrum antimicrobial activity. In this study, we performed the first exploratory analysis of rainbow trout Oncorhynchus mykiss brain proteins to identify theoretical antimicrobial patterns. More than half of the identified proteins were predicted to have antimicrobial regions. These proteins included histones, vitellogenin, collagen and others. The obtained results may prove to be of interest in the context of drug development based on peptides against various pathogens, which is a relevant direction against the backdrop of increasing antibiotic resistance of pathogenic microorganisms.