Email this article STRUCTURAL MECHANISM OF IONIC CONDUCTIVITY OF THE TRPV1 CHANNEL
- Authors: Trofimov Y.A.1,2, Minakov A.S.3, Krylov N.A.1,4, Efremov R.G.1,4,5
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Affiliations:
- Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
- National Research Nuclear University MEPhI (Moscow Engineering Physics Institute)
- Lomonosov Moscow State University
- National Research University Higher School of Economics
- Moscow Institute of Physics and Technology
- Issue: Vol 510, No 1 (2023)
- Pages: 247-251
- Section: Articles
- URL: https://journals.rcsi.science/2686-7389/article/view/135691
- DOI: https://doi.org/10.31857/S2686738923700221
- EDN: https://elibrary.ru/QIDHBZ
- ID: 135691
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Abstract
The so-called “hydrophobic gating” is widely discussed as a putative mechanism to control water and ion conduction via ion channels. This effect can occur in narrow areas of the channels pore lined by non-polar residues. In the closed state of the channel, such regions may spontaneously transit to a dehydrated state to block water and ions transport without full pore occlusion. In the open state, the hydrophobic gate is wide enough to provide sustainable hydration and conduction. Apparently, the transport through the open hydrophobic gate may by facilitated by some polar residues that assist polar/charged substances to overcome the energy barrier created by nonpolar environment. In this work, we investigated the behavior of Na+ ions and their hydration shells in the open pore of the rat TRPV1 ion channel by molecular dynamics simulations. We show that polar protein groups coordinate water molecules in such a way as to restore the hydration shell of ions in the hydrophobic gate that ensures ion transport through the gate in a fully hydrated state.
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About the authors
Yu. A. Trofimov
Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences; National Research Nuclear University MEPhI (Moscow Engineering Physics Institute)
Author for correspondence.
Email: YuTrofimov@gmail.com
Russian Federation, Moscow; Russian Federation, Moscow
A. S. Minakov
Lomonosov Moscow State University
Email: YuTrofimov@gmail.com
Russian Federation, Moscow
N. A. Krylov
Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences; National Research University Higher School of Economics
Email: YuTrofimov@gmail.com
Russian Federation, Moscow; Russian Federation, Moscow
R. G. Efremov
Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences; National Research University Higher School of Economics; Moscow Institute of Physics and Technology
Email: YuTrofimov@gmail.com
Russian Federation, Moscow; Russian Federation, Moscow; Russian Federation, Dolgoprudny
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