INTERACTOME OF PARAOXONASE PON2 REVEALS NEW PATHWAYS FOR TUMOR GROWTH REGULATION

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Abstract

The interactome of paraoxonase-2 encoded by the PON2 gene was investigated. A cDNA library was screened using a yeast two-hybrid system to search for new proteins interacting with human PON2. Analysis of the identified candidates, along with previously published data on interactors obtained by other methods, indicates the presence of a significant number of indirect interactions between PON2 and EGFR and, consequently, possible regulation of tumor growth with mutant EGFR involving PON2.

About the authors

V. D. Karlov

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry; All-Russia Research Institute of Agricultural Biotechnology

Email: tvkorn@gmail.com
Russian Federation, Moscow; Russian Federation, Moscow

N. B. Pestov

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry; Moscow Institute of Physics and Technology; Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences; Institute of Biomedical Chemistry

Email: tvkorn@gmail.com
Russian Federation, Moscow; Russian Federation, Dolgoprudny, Moscow Region; Russian Federation, Moscow; Russian Federation, Moscow

M. I. Shakhparonov

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry

Email: tvkorn@gmail.com
Russian Federation, Moscow

T. V. Korneenko

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry

Author for correspondence.
Email: tvkorn@gmail.com
Russian Federation, Moscow

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