APPROBATION OF A NEW MODEL OF SECONDARY DAMAGE AFTER TRAUMATIC BRAIN INJURY BASED ON REPROGRAMMED RAT EMBRYO FIBROBLASTS

E. B. Rykunova; Рыкунова Е. Б.; M. A. Mikeladze; Микеладзе М. А.; I. A. Utepova; Утепова И. А.; O. N. Chupakhin; Чупахин О. Н.; I. V. Guzhova; Гужова И. В.; V. F. Lazarev; Лазарев В. Ф.

doi:10.31857/S2686738923700312

APPROBATION OF A NEW MODEL OF SECONDARY DAMAGE AFTER TRAUMATIC BRAIN INJURY BASED ON REPROGRAMMED RAT EMBRYO FIBROBLASTS

Authors: Rykunova E.B.¹, Mikeladze M.A.¹, Utepova I.A.²^,3, Chupakhin O.N.²^,3, Guzhova I.V.¹, Lazarev V.F.¹
Affiliations:
1. Institute of Cytology of the Russian Academy of Sciences
2. Ural Federal University
3. Institute of Organic Synthesis of the Ural Branch of the Russian Academy of Sciences
Issue: Vol 511, No 1 (2023)
Pages: 399-404
Section: Articles
URL: https://journals.rcsi.science/2686-7389/article/view/135667
DOI: https://doi.org/10.31857/S2686738923700312
EDN: https://elibrary.ru/JLLFST
ID: 135667

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Abstract

The paper presents a new model of secondary injuries after traumatic brain injury. The model is based on the cultivation of rat embryonic fibroblasts reprogrammed to a neuronal phenotype in the presence of cerebrospinal fluid from injured rats. The presented model was used to test the therapeutic effect of inducers of the synthesis of chaperones from the classes of pyrrolyl- and indolylazines, which have neuroprotective properties.

Keywords

traumatic brain injury, cerebrospinal fluid, secondary injuries, chaperones, Hsp70, pyrrolyl- and indolylazine derivatives

About the authors

E. B. Rykunova

Institute of Cytology of the Russian Academy of Sciences

Email: lazarev@incras.ru
Russian Federation, St. Petersburg

M. A. Mikeladze

Institute of Cytology of the Russian Academy of Sciences

Email: lazarev@incras.ru
Russian Federation, St. Petersburg

I. A. Utepova

Ural Federal University; Institute of Organic Synthesis of the Ural Branch of the Russian Academy of Sciences

Email: lazarev@incras.ru
Russian Federation, Yekaterinburg; Russian Federation, Yekaterinburg

O. N. Chupakhin

Ural Federal University; Institute of Organic Synthesis of the Ural Branch of the Russian Academy of Sciences

Email: lazarev@incras.ru
Russian Federation, Yekaterinburg; Russian Federation, Yekaterinburg

I. V. Guzhova

Institute of Cytology of the Russian Academy of Sciences

Email: lazarev@incras.ru
Russian Federation, St. Petersburg

V. F. Lazarev

Institute of Cytology of the Russian Academy of Sciences

Author for correspondence.
Email: lazarev@incras.ru
Russian Federation, St. Petersburg

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