Computational Approaches for 2D and 3D Modeling of the Macro-Architecture of Native Chromosomes in Sperm Genome of Drosophila Melanogaster

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Abstract

As a first justified concept over 125 years of the history of the basic scientific ideas on the large-scale arrangement of eukaryotic interphase chromatin in cell nucleus, 2D and 3D spatial macro-architecture of haploid chromosomes in Drosophila sperm nucleus was sequentially reconstructed using the detected non-random distribution of -ray- and neutron-induced inversion and translocation breakpoints along the euchromatic chromosome maps with their clastering around heterochromatin.

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I D Alexandrov

Joint Institute for Nuclear Research

Email: igdon@jinr.ru
Лаборатория ядерных проблем им. В.П. Джелепова; Объединённый институт ядерных исследований; Joint Institute for Nuclear Research

M V Alexandrova

Joint Institute for Nuclear Research

Email: igdon@jinr.ru
Лаборатория ядерных проблем им. В.П. Джелепова; Объединённый институт ядерных исследований; Joint Institute for Nuclear Research

V V Ivanov

Joint Institute for Nuclear Research

Email: ivanov@jinr.ru
Лаборатория информационных технологий; Объединённый институт ядерных исследований; Joint Institute for Nuclear Research

V A Stepanenko

Joint Institute for Nuclear Research

Email: ivanov@jinr.ru
Объединённый институт ядерных исследований; Joint Institute for Nuclear Research

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