Impact of perioperative high-protein nutritional support on postoperative outcomes in the treatment of primary lung cancer: Russian prospective multicenter comparative study (NUTRILUNC-study)
- 作者: Obukhova O.1, Kurmukov I.1, Egofarov N.2, Kolesnichenko M.3,4, Kirillov Y.3,4, Povaga S.5, Belyaeva N.6, Gordeeva E.7, Perminov Y.8, Skorokhod A.8, Nefedov A.8, Novitsky D.9, Egofarov T.10
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隶属关系:
- N.N. Blokhin National Medical Research Center of Oncology
- Nutricia LLC
- Medical Center “Verax-Med” LLC
- North-Western State Medical University named after I.I. Mechnikov
- Smolensk Regional Clinical Oncology Dispensary
- Clinical hospital “Russian Railways-Medicine”
- Moscow Multidisciplinary Center for Palliative Care
- Saint Petersburg State Research Institute of Phthisiopulmonology
- Clinical Oncology Dispensary
- Medical University REAVIZ
- 期: 卷 4, 编号 3 (2023)
- 页面: 150-164
- 栏目: Original Study Articles
- URL: https://journals.rcsi.science/2658-4433/article/view/256756
- DOI: https://doi.org/10.17816/clinutr625481
- ID: 256756
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BACKGROUND: Up to 60% of lung cancer pts experience weight loss. Prevalence of sarcopenia in patients (pts) with non-small cell lung cancer (NSCLC) is about 43% and is an independent predictor of worse overall survival. It was shown that nutritional support improves outcomes in pts with cancer.
AIM: To evaluate impact of perioperative nutritional support on surgical treatment outcomes of patients with NSCLC.
MATERIALS AND METHODS: Patients with primary NSCLC (n=112, 69 males), aged 57,2±8,2, awaiting lung surgery and being at risk of malnutrition (Nutritional Risk Screening Assessment 2002 score ≥3) were randomized into 2 groups. Study group (n=55) received oral nutritional support (Nutridrink Compact Protein, Nutricia LLC), 250 ml/d (36 g of protein, 612 kcal) for 14 d before and 14 d after surgery in addition to standard diet. Control group (n=57) had a standard diet. The number of respiratory complications after surgery, length of hospitalization, anthropometric, functional, laboratory parameters, quality of life (according to Quality of Life Questionnaire Core-30) were assessed. Results were presented as mean ± standard deviation. Differences were considered significant at p ≤0.05.
RESULTS: In the study group there were fewer respiratory complications (p <0.01), and a shorter length of hospitalization (p=0.03). Body weight in the study group did not change significantly, while in the control group it decreased (0.15±3.7 kg versus loss of 3.47±3.6 kg). Results of six-minute walk test and hand grip dynamometry were higher in the study group then in the control group (411.8±56.0 m versus 383.2±52.1 m; 33.5±8.4 kg versus 27.1±6.8 kg). Quality of life was better in the study group, p <0.05. The total protein and albumin levels were higher in the study group (70.9±5.6 g/l versus 63.1±4.0 g/l; 38.5±5.8 g/l versus 33.2±3.0 g/l). One patient in study group experienced 1st grade diarrhea.
CONCLUSION: In patients with NSCLC at risk of malnutrition perioperative nutritional support with high protein oral nutritional support has a positive effect on surgical treatment outcomes.
作者简介
Olga Obukhova
N.N. Blokhin National Medical Research Center of Oncology
编辑信件的主要联系方式.
Email: obukhova0404@yandex.ru
ORCID iD: 0000-0003-0197-7721
SPIN 代码: 6876-7701
MD, Cand. Sci. (Medicine)
俄罗斯联邦, MoscowIldar Kurmukov
N.N. Blokhin National Medical Research Center of Oncology
Email: kurmukovia@gmail.com
ORCID iD: 0000-0001-8463-2600
SPIN 代码: 3692-5202
MD, Cand. Sci. (Medicine)
俄罗斯联邦, MoscowNail Egofarov
Nutricia LLC
Email: nail.egofarov@danone.com
ORCID iD: 0000-0001-5013-0231
俄罗斯联邦, Moscow
Mariya Kolesnichenko
Medical Center “Verax-Med” LLC; North-Western State Medical University named after I.I. Mechnikov
Email: maria_2182@mail.ru
MD, Cand. Sci. (Medicine)
俄罗斯联邦, Saint Petersburg; Saint PetersburgYuriy Kirillov
Medical Center “Verax-Med” LLC; North-Western State Medical University named after I.I. Mechnikov
Email: Yura-1992@mail.ru
SPIN 代码: 1186-9704
俄罗斯联邦, Saint Petersburg; Saint Petersburg
Svetlana Povaga
Smolensk Regional Clinical Oncology Dispensary
Email: povaga1980@mail.ru
ORCID iD: 0000-0001-6606-606X
俄罗斯联邦, Smolensk
Natal’ya Belyaeva
Clinical hospital “Russian Railways-Medicine”
Email: n.makar1973@mail.ru
ORCID iD: 0000-0001-9616-0030
俄罗斯联邦, Smolensk
Ekaterina Gordeeva
Moscow Multidisciplinary Center for Palliative Care
Email: simmetria0@mail.ru
SPIN 代码: 9814-3379
俄罗斯联邦, Moscow
Yuriy Perminov
Saint Petersburg State Research Institute of Phthisiopulmonology
Email: iuriiperminov88@gmail.com
俄罗斯联邦, Saint Petersburg
Andrey Skorokhod
Saint Petersburg State Research Institute of Phthisiopulmonology
Email: dr.skorokhod@mail.ru
ORCID iD: 0000-0002-1819-7206
SPIN 代码: 6609-6890
MD, Cand. Sci. (Medicine)
俄罗斯联邦, Saint PetersburgAndrey Nefedov
Saint Petersburg State Research Institute of Phthisiopulmonology
Email: herurg78@mail.ru
ORCID iD: 0000-0001-6228-182X
SPIN 代码: 2365-9458
MD, Cand. Sci. (Medicine)
俄罗斯联邦, Saint PetersburgDmitriy Novitsky
Clinical Oncology Dispensary
Email: dnn1978@gmail.com
俄罗斯联邦, Omsk
Timur Egofarov
Medical University REAVIZ
Email: tim7903@gmail.com
ORCID iD: 0009-0007-3620-7811
俄罗斯联邦, Samara
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