Effect of Keggin Heteropoly Acids on Human Embryo Fibroblast Cells

Resumo

The strong dependence of cytotoxicity of Keggin heteropoly acids [XM₁₂O₄₀]^n–, X = Si or P, M = Mo and W, n = 3 or 4 on chemical composition is demonstrated using the example of human embryo fibroblast cells based on the results of diagnostics using impedance monitoring, scanning electron microscopy, and measurements of visible cell sizes. The explanation of this dependence based on the role of hydrolytic stability of multiply charged anions in the development of cytotoxicity of these compounds is suggested. The results make it possible to suggest a new mechanism for the development of selectivity of polyoxometalate cytotoxicity relative to the studied cells. The differentiated cytotoxic activity of polyoxometalates relative to oncogenic cells is predicted.