Facile Synthesis of Ultrasmall, Highly Stable, and Biocompatible Gold Nanoparticles Stabilized with Lipoic Acid: Cytotoxicity and Structural Characterization

Delfino Cornejo-Monroy; Betania Sánchez-Santamaria; Erwin Adán Martínez-Gómez; Imelda Olivas-Armendáriz; Alfredo Villanueva-Montellano; José Saúl Arias-Cerón; Victor M. Castaño

doi:10.1134/S199507801906003X

Facile Synthesis of Ultrasmall, Highly Stable, and Biocompatible Gold Nanoparticles Stabilized with Lipoic Acid: Cytotoxicity and Structural Characterization

Authors: Cornejo-Monroy D.¹, Sánchez-Santamaria B.¹, Martínez-Gómez E.A.¹, Olivas-Armendáriz I.¹, Villanueva-Montellano A.¹, Arias-Cerón J.S.², Castaño V.M.³
Affiliations:
1. Universidad Autónoma de Ciudad Juárez, Colonia Partido Romero
2. Centro de Investigación y de Estudios Avanzados del I.P.N.
3. Universidad Nacional Autónoma de México, Querétaro
Issue: Vol 14, No 11-12 (2019)
Pages: 607-612
Section: Nanobiomedicine and Nanopharmaceuticals
URL: https://journals.rcsi.science/2635-1676/article/view/220902
DOI: https://doi.org/10.1134/S199507801906003X
ID: 220902

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Abstract

Using the colloidal method, and lipoic acid as a stabilizer, ultrasmall gold nanoparticles with an average size of 2.5 nm were synthesized. They are highly stable, have COOH functional groups, at concentrations lower than 100 μg/mL are non-cytotoxic, and the synthesis route is simple and economical. UV–Vis, FT-IR, Raman, and TEM spectroscopy were used to analyze their stability, composition and morphology. Furthermore, the cytotoxicity of the gold nanoparticles was evaluated by MTT assay.