Assessment of Hemocompatibility of Nanostructured Hydroxyapatite Spheres of Various Sizes

Abstract

Synthetic nanostructured hydroxyapatite is promising for a wide range of problems in reconstructive medicine and implantology, as well as in cosmetology and dentistry. By changing the synthesis conditions, it is possible for each specific application to adjust the characteristics of the material in accordance with the task. Samples of nanostructured hydroxyapatite with different compositions and granule size were obtained by chemical deposition followed by spray drying with ultrasound treatment. Analysis of the hemocompatibility of materials in experiments with mononuclear leukocytes and mouse blood erythrocytes showed that the obtained granule samples at a concentration of 40 mg per 2 mL of cell suspension are hemocompatible in all studied parameters, regardless of the size and composition of spheres.