Composite Nanoparticles Based on the Lexan Polymer Matrix, Ytterbium Complexes of Porphyrins, and Iron Oxide for NIR Luminescent Diagnostics and Neoplasm Theranostics


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Resumo

The synthesis procedure and the spectral luminescent properties of nanoparticles containing the ytterbium complex of protoporphyrin IX dimethyl ester in a Lexan-based polymer matrix, promising for application in neoplasm diagnostics, are described. Nanoparticles have an increased luminescence lifetime in the 700–1100 nm near infrared region and almost no porphyrin free base fluorescence in the red spectral region, which shows promise in using the nanoparticles for diagnostic purposes. For theranostic purposes, the synthesis of multifunctional nanoparticles with a core of iron oxides and a Lexan-polymer shell containing the ytterbium complex of hematoporphyrin IX tetramethyl ester was carried out. We assume iron oxide nanoparticles are responsible for the local hyperthermia procedure.

Sobre autores

N. Ivanovskaya

State Research Institute of Biological Instrumentation, Federal Medical-Biological Agency

Email: laserlab@ms.ire.rssi.ru
Rússia, Moscow, 125424

I. Shilov

Fryazino Branch, Kotelnikov Institute of Radio Engineering and Electronics, Russian Academy of Sciences

Email: laserlab@ms.ire.rssi.ru
Rússia, Fryazino, 141190

A. Ivanov

Skobelkin State Scientific Center of Laser Medicine, Federal Medical-Biological Agency; Blokhin National Medical Research Center of Oncology, Ministry of Healthcare of the Russian Federation

Email: laserlab@ms.ire.rssi.ru
Rússia, Moscow, 121165; Moscow, 115478

V. Rumyantseva

Fryazino Branch, Kotelnikov Institute of Radio Engineering and Electronics, Russian Academy of Sciences; MIREA–Russian Technological University

Autor responsável pela correspondência
Email: laserlab@ms.ire.rssi.ru
Rússia, Fryazino, 141190; Moscow, 119571

A. Gorshkova

Fryazino Branch, Kotelnikov Institute of Radio Engineering and Electronics, Russian Academy of Sciences

Email: laserlab@ms.ire.rssi.ru
Rússia, Fryazino, 141190

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