ANALYSIS OF THE TOXICITY OF GADOLINIUM NANOCOMPOSITES
- Авторлар: Titov E.A.1, Sosedova L.M.1, Novikov M.A.1
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Мекемелер:
- East Siberian Institute of Medical and Environmental Research
- Шығарылым: Том 14, № 3-4 (2019)
- Беттер: 144-148
- Бөлім: Nanobiomedicine and Nanopharmaceuticals
- URL: https://journals.rcsi.science/2635-1676/article/view/220753
- DOI: https://doi.org/10.1134/S1995078019020137
- ID: 220753
Дәйексөз келтіру
Аннотация
Abstract—The article presents theresults of a biosafety study of two gadolinium nanocomposites encapsulated in the natural polymer matrix of arabinogalactan and gives a comparative assessment of their toxicity. A probe was used to administer per os white outbred male rats with a solution of the studied nanocomposites in a dose of 500 μg gadolinium per kilogram of animal body weight. Histological and immunohistochemical analysis was applied to assay the severity of an organism’s biological response to these introduced nanocomposites. The state of liver tissue and the sensorimotor cortex were evaluated. In brain tissue, the number of neurons with expression of proapoptotic caspase 3 protein, antiapoptotic bcl-2 protein, and HSP stress protein 70 were determined. The authors determined the general points of application of the pathological process under the action of the studied nanocomposites and individual features of formation of the pathological process for each nanocomposite.
Авторлар туралы
E. Titov
East Siberian Institute of Medical and Environmental Research
Хат алмасуға жауапты Автор.
Email: g57097@yandex.ru
Ресей, Angarsk, 665826
L. Sosedova
East Siberian Institute of Medical and Environmental Research
Email: g57097@yandex.ru
Ресей, Angarsk, 665826
M. Novikov
East Siberian Institute of Medical and Environmental Research
Email: g57097@yandex.ru
Ресей, Angarsk, 665826
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