Hybrid Systems of Delivery of Long-Acting Drugs Based on Gentamicin Sulfate, Silver, and Copper Nanoparticles, and Gelatin Biopolymer Matrices
- Autores: Shabatina T.I.1, Vernaya O.I.1, Karlova D.L.1, Nuzhdina A.V.1, Shabatin V.P.1, Semenov A.M.1, Lozinskii V.I.2, Mel’nikov M.Y.1
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Afiliações:
- Moscow State University
- Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences
- Edição: Volume 13, Nº 9-10 (2018)
- Páginas: 546-550
- Seção: Nanobiology
- URL: https://journals.rcsi.science/2635-1676/article/view/220656
- DOI: https://doi.org/10.1134/S1995078018050130
- ID: 220656
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Resumo
Using the method of cryochemical synthesis, systems of prolonged release of gentamicin sulfate modified with silver (2–30 nm) and copper (1–9 nm) nanoparticles from cryostructured biopolymer matrices based on gelatin with a pore size of 10‒50 μm are obtained. The composition and structure of the systems are confirmed by the data of IR, UV, and NMR spectroscopy; TEM; SEM; and thermoanalytical methods of analysis, and the rate of release of the drug is determined by conductometry. Hybrid composites based on metals and gentamicin sulfate showed greater activity in suppressing the growth of E. coli 52 and S. aureus 144 than their components separately.
Sobre autores
T. Shabatina
Moscow State University
Autor responsável pela correspondência
Email: tatyanashabatina@yandex.ru
Rússia, Moscow, 119991
O. Vernaya
Moscow State University
Email: tatyanashabatina@yandex.ru
Rússia, Moscow, 119991
D. Karlova
Moscow State University
Email: tatyanashabatina@yandex.ru
Rússia, Moscow, 119991
A. Nuzhdina
Moscow State University
Email: tatyanashabatina@yandex.ru
Rússia, Moscow, 119991
V. Shabatin
Moscow State University
Email: tatyanashabatina@yandex.ru
Rússia, Moscow, 119991
A. Semenov
Moscow State University
Email: tatyanashabatina@yandex.ru
Rússia, Moscow, 119991
V. Lozinskii
Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences
Email: tatyanashabatina@yandex.ru
Rússia, Moscow, 119334
M. Mel’nikov
Moscow State University
Email: tatyanashabatina@yandex.ru
Rússia, Moscow, 119991
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