Nano- and Microfibrous Materials Based on Collagen for Tissue Engineering: Synthesis, Structure, and Properties
- Авторы: Tenchurin T.K.1, Istranov L.P.2, Istranova E.V.2, Shepelev A.D.1, Mamagulashvili V.G.1, Malakhov S.N.1, Kamyshinskii R.A.1, Orekhov A.S.1,2, Vasil’ev A.L.1,2, Sytina E.V.1, Krasheninnikov S.V.1, Chvalun S.N.1
- 
							Учреждения: 
							- National Research Center Kurchatov Institute
- Institute of Regenerative Medicine, Sechenov First Moscow State Medical University
 
- Выпуск: Том 13, № 9-10 (2018)
- Страницы: 476-486
- Раздел: Functional Nanomaterials
- URL: https://journals.rcsi.science/2635-1676/article/view/220628
- DOI: https://doi.org/10.1134/S1995078018050154
- ID: 220628
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Аннотация
The creation of three-dimensional structures possessing biomimetic properties is of considerable interest for regenerative medicine. Nonwoven materials with a diameter of fibers from 100 nm to 3 µm have been obtained by electrospinning from dispersions of collagen in hexafluoroisopropanol and acetic acid (AA). A study by the circular dichroism method indicates the predominant preservation of a collagen triple helix in produced materials. To preserve the fibrous structure in aqueous media, collagen is cross-linked by genipin in isopropanol and PBS (phosphate buffered saline, pH 7.4). The mechanical and biological properties of cross-linked materials have been studied—it is shown that the mechanical behavior of collagen materials in the physiological range of loads corresponds to the mechanical behavior of the native aorta. Cross-linked fibrous materials do not possess cytotoxicity, and they contribute to the adhesion and proliferation of cells.
Об авторах
T. Tenchurin
National Research Center Kurchatov Institute
							Автор, ответственный за переписку.
							Email: tenchurin.timur@mail.ru
				                					                																			                												                	Россия, 							Moscow, 123182						
L. Istranov
Institute of Regenerative Medicine, Sechenov First Moscow State Medical University
														Email: tenchurin.timur@mail.ru
				                					                																			                												                	Россия, 							Moscow, 119991						
E. Istranova
Institute of Regenerative Medicine, Sechenov First Moscow State Medical University
														Email: tenchurin.timur@mail.ru
				                					                																			                												                	Россия, 							Moscow, 119991						
A. Shepelev
National Research Center Kurchatov Institute
														Email: tenchurin.timur@mail.ru
				                					                																			                												                	Россия, 							Moscow, 123182						
V. Mamagulashvili
National Research Center Kurchatov Institute
														Email: tenchurin.timur@mail.ru
				                					                																			                												                	Россия, 							Moscow, 123182						
S. Malakhov
National Research Center Kurchatov Institute
														Email: tenchurin.timur@mail.ru
				                					                																			                												                	Россия, 							Moscow, 123182						
R. Kamyshinskii
National Research Center Kurchatov Institute
														Email: tenchurin.timur@mail.ru
				                					                																			                												                	Россия, 							Moscow, 123182						
A. Orekhov
National Research Center Kurchatov Institute; Institute of Regenerative Medicine, Sechenov First Moscow State Medical University
														Email: tenchurin.timur@mail.ru
				                					                																			                												                	Россия, 							Moscow, 123182; Moscow, 119991						
A. Vasil’ev
National Research Center Kurchatov Institute; Institute of Regenerative Medicine, Sechenov First Moscow State Medical University
														Email: tenchurin.timur@mail.ru
				                					                																			                												                	Россия, 							Moscow, 123182; Moscow, 119991						
E. Sytina
National Research Center Kurchatov Institute
														Email: tenchurin.timur@mail.ru
				                					                																			                												                	Россия, 							Moscow, 123182						
S. Krasheninnikov
National Research Center Kurchatov Institute
														Email: tenchurin.timur@mail.ru
				                					                																			                												                	Россия, 							Moscow, 123182						
S. Chvalun
National Research Center Kurchatov Institute
														Email: tenchurin.timur@mail.ru
				                					                																			                												                	Россия, 							Moscow, 123182						
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