Design of Nanodispersed Magnetoactive Systems for Targeted Drug Delivery

Abstract

Based on the method of thermal solvent precipitation, unique procedures for drug capsulation have been developed. Biodegradable polymers, polycaprolactone, and polyethylene glycol are used. Hydrosols and alcosols of various metals and their compounds have been obtained, which makes the targeted delivery of the desired substance using a magnetic field possible. The importance of magnetite hydrosol in the stability of colloidal systems has been shown. Experiments on the impact of doxorubicin and capsulated doxorubicin on the HeLa cell culture are carried out. The studies are conducted in laboratory mice and the possibility of controlling magnetoactive particles in vivo is demonstrated.