Morphological Characteristics of Hippocampus under the Action of Titan Dioxide Nanoparticles in Rats

Abstract

In this work the reactive changes in rat hippocampus in response to intranasal administration of TiO₂ nanoparticles (NPs) have been studied. The immunohistochemistry of animal hippocampi has shown an increase in the sensitivity of vascular endotheliocytes and macroglia to the vascular endothelial growth factor (VEGF) in hippocampi of the experimental group. The expression of the glial fibrillary acidic protein (GFAP) has been found to enhance, suggesting the increment of the reactive astrocytes amount in the studied brain area under the action of TiO₂ NPs. According to the results of this research, we have deduced the compensatory reactions in hippocampus accompanied by astrocytic activation, processes of angiogenesis, and the impairment of neurogliar ratio under the action of TiO₂ NPs.