Low molecular weight poly(3-hydroxybutyrate) microparticles synthesized by piezoelectric spray drying for the sustained release of paclitaxel
- Autores: Zernov A.L.1, Bonartsev A.P.1,2, Yakovlev S.G.1, Myshkina V.L.1, Makhina T.K.1, Parshina E.S.2, Kharitonova E.P.3, Bonartseva G.A.1, Shaitan K.V.2
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Afiliações:
- Federal Research Centre “Fundamentals of Biotechnology” of the Russian Academy of Sciences, A.N. Bach Biochemistry Institute
- Faculty of Biology
- Faculty of Physics
- Edição: Volume 12, Nº 3-4 (2017)
- Páginas: 218-225
- Seção: Article
- URL: https://journals.rcsi.science/2635-1676/article/view/219977
- DOI: https://doi.org/10.1134/S1995078017020136
- ID: 219977
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Resumo
Biocompatible and biodegradable polymer microparticles are contemporary medicines able to eliminate the side effects and unsatisfactory pharmacokinetics of already existing preparations. In this work we have developed a high-tech scalable method for the synthesis of paclitaxel-loaded poly(3-hydroxybutyrate) (PHB)-based microparticles. These particles were synthesized on a B-90 Buchi nano spray dryer by piezoelectric spray drying in an inert atmosphere. A regular spherical shape, narrow size distribution, and satisfactory results for the release of paclitaxel from the polymeric matric of microparticles in vitro make this polymeric medicinal form promising for its further application in pharmaceutics. Nanoparticles with a similar composition synthesized via the laboratory one-stage emulsification method were used for comparison. This study is the first stage in the creation of a sustained-action anticancer paclitaxel preparation.
Sobre autores
A. Zernov
Federal Research Centre “Fundamentals of Biotechnology” of the Russian Academy of Sciences, A.N. Bach Biochemistry Institute
Autor responsável pela correspondência
Email: zernovanton89@gmail.com
Rússia, Moscow, 119071
A. Bonartsev
Federal Research Centre “Fundamentals of Biotechnology” of the Russian Academy of Sciences, A.N. Bach Biochemistry Institute; Faculty of Biology
Email: zernovanton89@gmail.com
Rússia, Moscow, 119071; Moscow, 119234
S. Yakovlev
Federal Research Centre “Fundamentals of Biotechnology” of the Russian Academy of Sciences, A.N. Bach Biochemistry Institute
Email: zernovanton89@gmail.com
Rússia, Moscow, 119071
V. Myshkina
Federal Research Centre “Fundamentals of Biotechnology” of the Russian Academy of Sciences, A.N. Bach Biochemistry Institute
Email: zernovanton89@gmail.com
Rússia, Moscow, 119071
T. Makhina
Federal Research Centre “Fundamentals of Biotechnology” of the Russian Academy of Sciences, A.N. Bach Biochemistry Institute
Email: zernovanton89@gmail.com
Rússia, Moscow, 119071
E. Parshina
Faculty of Biology
Email: zernovanton89@gmail.com
Rússia, Moscow, 119234
E. Kharitonova
Faculty of Physics
Email: zernovanton89@gmail.com
Rússia, Moscow, 119991
G. Bonartseva
Federal Research Centre “Fundamentals of Biotechnology” of the Russian Academy of Sciences, A.N. Bach Biochemistry Institute
Email: zernovanton89@gmail.com
Rússia, Moscow, 119071
K. Shaitan
Faculty of Biology
Email: zernovanton89@gmail.com
Rússia, Moscow, 119234
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