Microwave synthesis of core–shell nanosize materials on the basis of magnetite functionalized with gold and doxorubicine

Abstract

A method for the microwave synthesis of multifunctional magnetic nanomaterials with a “core–multilayered shell” structure is proposed. The optimal conditions for the step-by-step synthesis of a material on the basis of magnetite Fe₃O₄ (“core”) modified by silicon-containing polymers (ТEOS + MPTMS), gold nanoparticles, and immobilized antineoplastic drug doxorubicine (DOX) (“shell”) are found. Using instrumental techniques, the composition of the prepared nanomaterials (Fe₃O₄@TEOS/MPTMS@Au_coll@DOX) is investigated and the sizes of particles synthesized at different temperatures and reagent ratios are determined. The sorption processes involving DOX and synthesized nanomaterials are studied at different phase contact times, doxorubicine concentration, and рН of the medium. The possibility of controlled release of DOX from the nanoparticle surface upon changing the рН value is demonstrated. The synthesized hybrid nanoparticles could be promising for different biomedical applications, in particular, for targeted drug delivery and local hyperthermia.