Reviews and Advances in Chemistry
Reviews and Advances in Chemistry is an international peer-reviewed journal. It provides an international forum for publishing cutting-edge, rigorous, high-impact research across all of chemistry, materials science, and chemical engineering. This broad scope encompasses studies on all aspects of contemporary chemical sciences and engineering, including, but not limited to, basic and applied topical aspects of organic, inorganic, organoelement, physical, solid state, supramolecular, polymer, colloidal, nanoscience, soft matter, biological, medicinal, pharmaceutical, analytical, theoretical, cheminformatics, computational and mathematical chemistry, radio-, photo-, electro- and mechanochemistry, as well as chemical engineering, materials processing, food science, environmental issues, and safety. Interdisciplinary articles and papers in all chemistry-related areas are also welcome. In addition to comprehensive, focused and unsolicited critical reviews, Reviews and Advances in Chemistry also publishes ordinary research articles, short communications, and letters to the editor, which report new methods of particular interest to the chemistry community. The editorial board of Reviews and Advances in Chemistry includes the world's leading experts in the main fields of chemistry. The journal sees the main priority in the development of Reviews and Advances in Chemistry to become a major contributor to the science publication ecosystem that serves scientists from around the globe. The journal implements rigorous and fair peer review of submitted articles that follow the best scientific and ethical standards. Reviews and Advances in Chemistry currently uses a single-blind peer review and will implement a double-blind peer review option soon. Reviews and Advances in Chemistry is published in English only. The journal offers hybrid open access and will work to attain full compliance with PlanS in the nearest future. The journal welcomes the pre-submission of papers into archives. Reviews and Advances in Chemistry is committed to diversity and equality and strives to overcome barriers not only between scientific disciplines but also between “young” and “established” researchers, “high” and “low” income counties, “East” and “West” mindsets, and other barriers that hinder science. The journal welcomes manuscripts from all countries. Reviews and Advances in Chemistry is guided by the quality of science and aims to take a leading position among the world chemical journals.
Peer review and editorial policy
The journal follows the Springer Nature Peer Review Policy, Process and Guidance, Springer Nature Journal Editors' Code of Conduct, and COPE's Ethical Guidelines for Peer-reviewers.
Approximately 3% of the manuscripts are rejected without review based on formal criteria as they do not comply with the submission guidelines. Each manuscript is assigned to at least one peer reviewer. The journal follows a single-blind reviewing procedure. The period from submission to the first decision is 25 days on average. The approximate rejection rate is 30%. The final decision on the acceptance of a manuscript for publication is made by the responsible editor.
If Editors publish in the journal, they do not participate in the decision-making process for manuscripts where they are listed as co-authors.
Special issues published in the journal follow the same procedures as all other issues. If not stated otherwise, special issues are prepared by the members of the Editorial Board without guest editors.
Current Issue
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Vol 9, No 4 (2019)
- Year: 2019
- Articles: 3
- URL: https://journals.rcsi.science/2634-8276/issue/view/13583
Article
Frontal Polymerization in Continuous-Flow Reactors
Abstract
This paper discusses the results of theoretical and experimental studies on the implementation of frontal polymerization in continuous-flow reactors of various geometric designs. The stationarity and stability of propagation of the front wave are shown to depend on macrokinetic and kinetic parameters. The effects of the feed rate, reactor dimensions, and concentration of the mixtures of initiators and polymer additives on the conversion rate and molecular-weight characteristics of the formed polymer are studied. The causes of frontal stationarity disturbance, which are manifested by the formation of nonlinear phenomena in the form of various oscillation modes, are revealed.
Brief characteristics of tubular reactors, as found theoretically and experimentally, and their shortcomings are presented. A cylindrical reactor for the frontal polymerization of methyl methacrylate is presented, which was developed at the Experimental Plant in Chernogolovka (Moscow oblast) and introduced into industrial production in Dzerzhinsk. A tubular reactor that was built in to a flow for the synthesis of hydrogels under the conditions of frontal polymerization is also presented.
175-196
The Structural Basis for the Production of Cancer and Detoxification by Oxidized Metabolites of Mesoanthracenic Methylated and Non-Methylated Polynuclear Hydrocarbons: a Paradigm Shift
Abstract
Although many attempts have been made since 1930 to explain the production of cancer in experimental animals by oxidized metabolites of polynuclear aromatic hydrocarbons (PAH) with either molecular structure types ArCH2X or ArX, the simplest interpretation is that one type must function in experimental animals to produce cancer, whereas the other structural type prevents the production of cancer by formation of detoxification products. The specific predictions of the Unified Theory of carcinogenesis by PAH or PACs (Polynuclear Aromatic Compounds) depends on the validity of the predictions for the production of cancer by PACs with structural types ArCH2X or ArX. These two structural types have been adopted as crucial models for PAC metabolites by Flesher, Sydnor and colleagues since the 1970s. We were aided by the experiments and strong inferences of Professors Fieser, Fried, Boyland, Sims, and Huggins, and the theoretical studies of a possible structure of the ultimate carcinogen for 7-methylbenz[a]anthracene and closely related hydrocarbons by Brookes and Dipple together with the calculations of Dewar that predict the most reactive centers for substitution reactions in unsubstituted hydrocarbons. Shear in the late 1930s and 1940s was the first to show that meso-aldehydes and meso-methyl-substituted hydrocarbons function as precursors to active compounds with structure type ArCH2X. The discoveries by Flesher, Sydnor and coworkers demonstrated that biological methylation must take place at the most reactive center in non-methylated hydrocarbons catalyzed by cytosolic SAM-dependent methyltransferases, and the methyl group must subsequently be hydroxylated and conjugated with a good leaving group, if the PAC is to be carcinogenic. This is precisely the same site of special reactivity required for methylation by chemical synthesis as calculated by the Dewar molecular orbital approach. Blocking the reactive center in the aromatic nucleus (in the form of products as ArX) with the same groups attached to the meso-methyl group of methyl-substituted hydrocarbons (in the form ArCH2X) which produces cancer typically abolishes the production of cancer. Consequently, no theory relating ring oxidation to the production of cancer can account for the fact that substitution of reactive centers in non-methylated hydrocarbons with hydroxy or acetoxy groups, while simultaneously blocking methylation, also abolish its carcinogenic activity. If alternative hypotheses or theories do not cite the fundamental studies of Fieser and of Shear and Leiter there is little possibility that the alternative theory is correct. It seems obvious that most, if not all, hypotheses or theories that attempt to relate ring oxidized metabolites of PAH to the production of cancer have been disproved.
197-254
A Recent Progress in Microwave-assisted Synthesis of Heterocyclic Compounds Containing Nitrogen, Sulphur and Oxygen
Abstract
Synthesis of heterocyclic compounds has constituted a major part of research in medicinal chemistry. In the last two decades, many of the heterocyclic rings were prepared with appreciable yield by using microwave-assisted synthesis. These rings are central core in a heterocyclic compound that offers different pharmacological activities to the needy. In recent times, the majority of the heterocyclic compounds are synthesized by researchers using this technique and satisfied with the quality and quantity of the product obtained from the respective raw materials. But, there is no review concerning about recent preparation of heterocyclic compounds using microwave-assisted synthesis. In the presented study, an attempt had been made to found out the newer heterocyclic compounds using microwave-assisted synthesis and their biological activities. This review emphasizes the two decades of research work on the preparation of heterocyclic compounds by using microwave-assisted synthesis.
255-289