Email this article Development of multifocal ischemic stroke after cessation of anticoagulant therapy in a patient with antiphospholipid syndrome
- Authors: Minina Y.D.1, Kalinin V.A.2
-
Affiliations:
- Samara Regional Clinical Hospital named after V.D. Seredavin
- Samara State Medical University
- Issue: Vol 6, No 3 (2021)
- Pages: 42-45
- Section: Diseases of the nervous system
- URL: https://journals.rcsi.science/2500-1388/article/view/81403
- DOI: https://doi.org/10.35693/2500-1388-2021-6-3-42-45
- ID: 81403
Cite item
Full Text
Abstract
The clinical case presents a young patient with antiphospholipid syndrome, which was the cause of recurrent acute ischemic cerebrovascular accidents and pathology of pregnancy.
During the clinical and laboratory examination, the patient was diagnosed with systemic lupus erythematosus. To determine the etiology of ischemic strokes and recurrent pregnancy loss, the patient underwent an immunological blood test which led to diagnosing the antiphospholipid syndrome. The patient failed to comply with the doctor's recommendations for taking an anticoagulant in the early postpartum period that resulted in the development of multifocal ischemic stroke.
After treatment, the patient's condition improved, focal neurological symptoms partially regressed, and laboratory parameters returned to normal. As a secondary prevention of thrombosis, the patient was prescribed anticoagulant therapy.
Full Text
##article.viewOnOriginalSite##About the authors
Yulia D. Minina
Samara Regional Clinical Hospital named after V.D. Seredavin
Author for correspondence.
Email: jminina1988@gmail.com
ORCID iD: 0000-0002-2992-6451
neurologist
Russian Federation, 159 Tashkentskаya st., Samara, 443095Vladimir A. Kalinin
Samara State Medical University
Email: jminina1988@gmail.com
ORCID iD: 0000-0003-3233-8324
PhD, Professor, Department of Neurology and neurosurgery
Russian Federation, SamaraReferences
- Negrini S, et al.The antiphospholipid syndrome: from pathophysiology to treatment. Clin Exp Med. 2017;17(3):257–267. doi: 10.1007/s10238-016-0430-5
- Arachchillage DRJ, Laffan M. Pathogenesis and management of antiphospholipid syndrome. Br J Haematol. 2017;178(2):181–195. doi: 10.1111/bjh.14632
- Gómez-Puerta JA, Cervera R. Diagnosis and classification of the antiphospholipid syndrome. J Autoimmun. 2014;48–49:20–25. doi: 10.1016/j.jaut.2014.01.006
- Cervera R. Antiphospholipid syndrome. Thromb Res. 2017;151(1):43–47. doi: 10.1016/S0049-3848(17)30066-X
- Khamashta MA. Hughes syndrome: antiphospholipid syndrome. London: Springer; 2000.
- Cervera R, Piette JC, Font J, et al. Euro-Phospholipid Project Group. Antiphospholipid syndrome: clinical and immunologic manifestations and patterns of disease expression in a cohort of 1,000 patients. Arthritis Rheum. 2002; 46(4):1019–27. doi: 10.1002/art.10187
- Andreoli L, et al. Estimated frequency of antiphospholipid antibodies in patients with pregnancy morbidity, stroke, myocardial infarction, and deep vein thrombosis: a critical review of the literature. Arthritis Care Res. (Hoboken). 2013;65(11):1869–1873. doi: 10.1002/acr.22066
- Rai R, Swetha T. Association of anti-phospholipid antibodies with connective tissue diseases. Indian Dermatol Online J. 2015;6(2):89–91. doi: 10.4103/2229-5178.153009
- Habe K. Presence of antiphospholipid antibodies as a risk factor for thrombotic events in patients with connective tissue diseases and idiopathic thrombocytopenic purpura. Intern Med. 2016;55(6):589–95. doi: 10.2169/internalmedicine.55.5536
- Aleksandrova EN, Reshetnyak TM, Novikov AA. Immunological characteristics of antiphospholipid syndrome. Russian Clinical Laboratory Diagnostics. 2005;(9):12a. (In Russ.). [Александрова ЕН, Решетняк ТМ, Новиков АА. Иммунологическая характеристика антифосфолипидного синдрома. Клиническая лабораторная диагностика. 2005;(9):12a].
- Pengo V, Tripodi A, Reber G, et al. Subcommittee on lupus anticoagulant/ antiphospholipid antibody of the scientific and standardization committee of the international society on thrombosis and haemostasis. Update of the guidelines for lupus anticoagulant detection. J Thromb Haemost. 2009;7(10):1737–40. doi: http:// dx.doi.org/10.1111/j.1538-7836.2009.03555.x
- Pengo V, Ruffatti A, Legnani C, et al. Clinical course of high-risk patients diagnosed with antiphospholipid syndrome. J Thromb Haemost. 2010;8(2):237–42. doi: http://dx.doi. org/10.1111/j.1538-7836.2009.03674.x
- Lateef A, Petri M. Managing lupus patients during pregnancy. Best Pract Res Clin Rheumatol. 2013;27:435–47. doi: 10.1016/j.berh.2013.07.005
- Smyth A, Garovic VD. Systemic lupus erythematosus and pregnancy. Minerva Urol Nefrol. 2009;61(4):457–74. PMID: 19816395
- Smyth A, Oliveria GH, Lahr BD, et al. A systematic review and metaanalysis of pregnancy outcomes in patients with systemic lupus erythematosus and lupus nephritis. Clin J Am Soc Nephrol. 2010;5(11):2060–8. doi: 10.2215/CJN.00240110
Supplementary files
