Idiopathic pulmonary hypertension (autopsy observation)
- Authors: Vasyukova O.A.1, Tsareva N.A.2,3, Chernyaev A.L.1,2,4,5, Mikhaleva L.M.1, Samsonova M.V.2,4,6
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Affiliations:
- B.V. Petrovsky Russian Research Center of Surgery
- Research Institute of Pulmonology of FMBA of Russia
- I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of Russia (Sechenov university)
- Central Research Institute of Tuberculosis
- N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia
- A.S. Loginov Moscow Clinical Research Center of the Department of Healthcare of Moscow
- Issue: Vol 9, No 6 (2023)
- Pages: 82-88
- Section: CLINICAL CASE
- URL: https://journals.rcsi.science/2412-4036/article/view/258876
- DOI: https://doi.org/10.18565/therapy.2023.6.82–88
- ID: 258876
Cite item
Abstract
The article presents a description of idiopathic pulmonary arterial hypertension (IPAH) autopsy observation. The diagnosis was made in a 51-year-old patient four years ago and based on the results of an invasive measurement of mean pulmonary artery pressure during right heart catheterization, the index of which was 36 mmHg. During dynamic observation, according to echocardiography, the values of systolic pressure in the pulmonary artery ranged from 66 to 107 mm Hg. Observed patient received treatment with macitentan and spironolactone for 4 years, died with symptoms of pulmonary heart disease. At autopsy, idiopathic plexiform arteriopathy was diagnosed in combination with Heth–Edwards class 4–5 thrombotic arteriopathy with right ventricular failure development.
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##article.viewOnOriginalSite##About the authors
Olesya A. Vasyukova
B.V. Petrovsky Russian Research Center of Surgery
Author for correspondence.
Email: o.vas.93@gmail.com
ORCID iD: 0000-0001-6068-7009
junior researcher at the Laboratory of clinical morphology, Scientific Research Institute of Human Morphology named after academician A.P. Avtsyn
Russian Federation, 117418, Moscow, 3 Tsyurupy Str.Natalya A. Tsareva
Research Institute of Pulmonology of FMBA of Russia; I.M. Sechenov First Moscow State Medical University of the Ministry of Healthcare of Russia (Sechenov university)
Email: tsareva_n_a@staff.sechenov.ru
ORCID iD: 0000-0001-9357-4924
phd in medical sciences, head of the laboratory of intensive care and respiratory failure, associate professor of the department of pulmonology
Russian Federation, 115682 Moscow, 28 Orekhovy Boulevard; MoscowAndrey L. Chernyaev
B.V. Petrovsky Russian Research Center of Surgery; Research Institute of Pulmonology of FMBA of Russia; Central Research Institute of Tuberculosis; N.I. Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russia
Email: cheral12@gmail.com
ORCID iD: 0000-0003-0973-9250
md, professor, head of the department of fundamental pulmonology, leading researcher at the Laboratory of clinical morphology, professor of the department of pathological anatomy and clinical pathological anatomical anatomy of the faculty of general medicine, pathologist, Scientific Research Institute of Human Morphology named after academician A.P. Avtsyn
Russian Federation, 115682, Moscow, 28 Orekhovy Boulevard; Moscow; Moscow; MoscowLyudmila M. Mikhaleva
B.V. Petrovsky Russian Research Center of Surgery
Email: mikhalevaLM@yandex.ru
ORCID iD: 0000-0003-2052-914X
md, professor, corresponding member of the Russian Academy of Sciences, director, head of the laboratory of clinical morphology, Scientific Research Institute of Human Morphology named after academician A.P. Avtsyn
Russian Federation, 117418, Moscow, 3 Tsyurupy Str.Maria V. Samsonova
Research Institute of Pulmonology of FMBA of Russia; Central Research Institute of Tuberculosis; A.S. Loginov Moscow Clinical Research Center of the Department of Healthcare of Moscow
Email: sama-ry@mail.ru
ORCID iD: 0000-0001-8170-1260
md, head of the laboratory of pathological anatomy, senior researcher
Russian Federation, 115682, Moscow, 28 Orekhovy Boulevard; Moscow; MoscowReferences
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