接种COVID-19疫苗后的死亡:临床病例

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降低传染病的死亡率和发病率需要疫苗。这一点在COVID-19大流行中尤为重要。世界各地已开发出不同类型的疫苗来应对大流行。然而,所有COVID-19疫苗类型都有接种后并发症的报道。其中一种并发症是过敏性休克。过敏性休克通常发生在曾经有过过敏反应的人身上。在印度,接种疫苗的人要在医疗机构接受30分钟的监督,因为在接种疫苗后几分钟到几小时内就会出现不良反应。

本文介绍一名23岁女性的案例。她在接种重组ChAdOx1 nCoV-19疫苗(COVISHIELD)24小时后去世了。在医疗机构随访期间,患者没有出现接种后症状。过去也未出现过敏反应。这名妇女被送到M.S.Ramaiah医学院附属医院(M.S.Ramaiah Medical College)时已经去世了。尸检显示了肺水肿。尸检血样显示了有COVID-19抗体、炎症标记物、血清IgE和血凝迹象。死因是对COVISHIELD疫苗的迟发型过敏反应。新一代疫苗可能会引起致命的过敏反应,有时比方案规定的时间更晚。即使没有皮肤反应,疫苗也可能引起致命的过敏反应。

作者简介

Jayanth S. Hosahally

Dr Chandramma Dayananda Sagar Institute of Medical Education & Research

Email: veejay02@gmail.com
ORCID iD: 0000-0001-5209-1133

MD, Associate Professor

印度, Devarakaggalahalli

Varsha Patil

Bangalore Medical College Bangalore

Email: dr.varshapatil93@gmail.com
ORCID iD: 0000-0002-5352-6810
印度, Bangalore

Girish Y.P. Chandra

MS Ramaiah Medical College

编辑信件的主要联系方式.
Email: girishchandra14@gmail.com
ORCID iD: 0000-0002-5446-8114

MD, Professor

印度, Bangalore

参考

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补充文件

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1. JATS XML
2. Fig. 1. Conjunctival congestion.

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3. Fig. 2. Cyanosis of nail beds.

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4. Fig. 3. Froth over both nostrils.

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5. Fig. 4. Intra muscular injection mark present over the outer aspect of left arm.

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6. Fig. 5. Froth and mucus in trachea.

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7. Fig. 6. Pulmonary oedema.

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