Death following COVID-19 vaccination: A case report
- Authors: Hosahally J.S.1, Patil V.2, Chandra G.Y.3
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Affiliations:
- Dr Chandramma Dayananda Sagar Institute of Medical Education & Research
- Bangalore Medical College Bangalore
- MS Ramaiah Medical College
- Issue: Vol 9, No 4 (2023)
- Pages: 447-455
- Section: CASE REPORTS
- URL: https://journals.rcsi.science/2411-8729/article/view/251339
- DOI: https://doi.org/10.17816/fm13497
- ID: 251339
Cite item
Abstract
Vaccines are necessary to reduce the mortality and morbidity of infectious diseases. It has played a vital role in the ongoing coronavirus disease 2019 (COVID-19) pandemic. Different types of vaccines have been developed to combat the pandemic. Adverse events following immunization including anaphylaxis have been reported for all types of COVID-19 vaccine. Anaphylaxis is common in a person who has a history of allergic reactions. Adverse reactions develop within minutes or a few hours after vaccination. Thus, in India, vaccine recipients are made to stay in the medical facility for 30 min for observation.
Herein, we report the case of a 23-year-old woman who succumbed after 24 hours of taking COVISHIELD ChAdOx1 nCoV-19 Corona Virus Vaccine (recombinant). She did not have any symptoms after vaccination during her observation at the medical facility and did not have a history of allergic reactions. She was brought dead to M.S. Ramaiah Hospital, and the autopsy revealed pulmonary edema. Antibodies to COVID-19, inflammatory markers, serum IgE, and coagulation indicators in the postmortem blood sample were high. The cause of death was attributed to a delayed allergic reaction to COVISHIELD vaccine. Newer vaccines can cause fatal allergic reaction, sometimes later than expected, even when cutaneous reactions may not be present.
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##article.viewOnOriginalSite##About the authors
Jayanth S. Hosahally
Dr Chandramma Dayananda Sagar Institute of Medical Education & Research
Email: veejay02@gmail.com
ORCID iD: 0000-0001-5209-1133
MD, Associate Professor
India, DevarakaggalahalliVarsha Patil
Bangalore Medical College Bangalore
Email: dr.varshapatil93@gmail.com
ORCID iD: 0000-0002-5352-6810
India, Bangalore
Girish Y.P. Chandra
MS Ramaiah Medical College
Author for correspondence.
Email: girishchandra14@gmail.com
ORCID iD: 0000-0002-5446-8114
MD, Professor
India, BangaloreReferences
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