自杀过程中神经元环境的形态及功能变化

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多年来，自杀行为的发展一直是一个热门话题。每年关于脑组织存在新形态变化的报告越来越多，并且考虑微环境对神经元功能活动的变化和影响，以及与某些精神疾病发展的关系。形态变化不一定很明显，也不一定很明确，所以人们考虑将胶质纤维酸性蛋白（GFAP）的免疫组化检测作为一种补充诊断方法。

这篇分析文献综述涉及自杀中小胶质细胞、星形胶质细胞、少突胶质细胞和血脑屏障的形态研究的状况。根据综合数据，自杀行为发展过程中最具代表性的局部变化是由中缝核、前额叶皮层和前扣带回皮层决定的。一些证据表明，自杀行为的发展与前额叶皮层中炎症细胞因子的增加、前扣带回皮层中星形胶质细胞和少突胶质细胞之间的交流受损相关，并表明壳核、纹状体、楔前叶和楔叶、眶额皮层参与自杀行为的形成。

确定自杀死亡的特有形态学有可能为确认或排除死因评估中的自杀发展因素提供证据基础。

需要进一步研究，以便更清楚地了解法医鉴定实践中的变化，并且免疫组化分析被认为是了解自杀因素的潜在证据基础。

作者简介

Maxim A. Kislov

I.M. Sechenov First Moscow State Medical Univesity; Moscow State Regional University

Email: kislov@1msmu.ru
ORCID iD: 0000-0002-9303-7640
SPIN 代码: 3620-8930

MD, Dr. Sci. (Med.), Professor

俄罗斯联邦, Moscow; Mytishchi

Daria S. Trusova

I.M. Sechenov First Moscow State Medical Univesity

编辑信件的主要联系方式.
Email: trusova_d_s@student.sechenov.ru
ORCID iD: 0000-0002-9062-8031
SPIN 代码: 6906-9238
Scopus 作者 ID: 57484068400
俄罗斯联邦, Moscow

Konstantin N. Krupin

I.M. Sechenov First Moscow State Medical Univesity; Scientific Research Laboratory of Human Morphology

Email: krupin@1msmu.ru
ORCID iD: 0000-0001-6999-8524
SPIN 代码: 1761-8559

MD, Cand. Sci. (Med.)

俄罗斯联邦, Moscow; Samara

Marianna S. Zhiganova

I.M. Sechenov First Moscow State Medical Univesity

Email: zhiganova.marianna@yandex.ru
ORCID iD: 0000-0003-1741-4229
SPIN 代码: 3031-8173
俄罗斯联邦, Moscow

Aleksandr V. Maksimov

Moscow State Regional University

Email: mcsim2004@inbox.ru
ORCID iD: 0000-0003-1936-4448
SPIN 代码: 3134-8457

MD, Dr. Sci. (Med), Assistant Professor

俄罗斯联邦, Mytishchi

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