Histomorphological changes in the lungs induced by poisoning with baclofen and its combination with ethanol (experimental study)

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 Aim. Detection and assessment of histomorphological changes in the lungs in acute poisoning with Baclofen and its combination with ethanol three hours after poisoning. Material and methods. Experimental studies were conducted in 15 Wistar lineage rats divided into three groups. The control group included five intact animals, group 1 was treated with Baclofen at a dose of 85 mg/kg, group 2 — with a combination of Baclofen (85 mg/kg) and ethanol (7 mL/kg of 40% ethanol). Results. No pathological changes were observed in the lungs of the controls. Both treated groups manifested the capillary and venous plethora, sludge syndrome, atelectases and dystelectases, emphysema and infiltration of white blood cells into the interalveolar septa. Bronchioles in the group 2 animals contained secretion. Conclusion. In the conducted trials, a complex of pathological changes was observed in the lungs of animal models shortly after the administration of Baclofen, including circulatory disorders in all departments of the microcirculatory bed (plethora of capillaries and venules), emphysema, atelectases and dystelectases, leucocyte infiltration into the interalveolar septa. Morphometric studies are necessary to quantify the severity of histomorphological changes in the lungs.

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Olga Romanova

Peoples’ Friendship University of Russia; Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology

编辑信件的主要联系方式.
Email: olgpharm@yandex.ru
ORCID iD: 0000-0001-6356-9251

Cand. Sci. (Biol.), Assoc. Prof. of the Department of Forensic Medicine, Peoples’ Friendship University of Russia; Senior Researcher, V. A. Negovsky Scientific Research Institute of General Reanimatology of the Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology

俄罗斯联邦, Moscow

Dmitriy Sundukov

Peoples’ Friendship University of Russia

Email: sudmed.rudn@yandex.ru
ORCID iD: 0000-0001-8173-8944

Dr. Sci. (Med.), Head of the Department of Forensic Medicine, Peoples’ Friendship University of Russia

俄罗斯联邦, Moscow

Arkadiy Golubev

Peoples’ Friendship University of Russia; Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology

Email: arkadygolubev@mail.ru

д.м.н., проф. кафедры судебной медицины ФГАОУ ВО РУДН; зав. лабораторией патологии клетки НИИ ОР ФНКЦ РР

俄罗斯联邦, Moscow

Mikhail Blagonravov

Peoples’ Friendship University of Russia

Email: blagonravov_ml@rudn.ru
ORCID iD: 0000-0001-7838-0486

Dr. Sci. (Med.), Head of the Department of General Pathology and Pathological Physiology named after V. A. Frolov, Peoples’ Friendship University of Russia

俄罗斯联邦, Moscow

Anton Ershov

Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology; I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: salavatprof@mail.ru
ORCID iD: 0000-0001-5758-8552

Dr. Sci. (Med.), Assoc. Prof., Leading Researcher, Laboratory of Experimental Studies, V. A. Negovsky Scientific Research Institute of General Reanimatology of the Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology; Prof., I. M. Sechenov First Moscow State Medical University

俄罗斯联邦, Moscow

参考

  1. Baclofen Monograph for Professionals. Drugs.com. American Society of Health-System Pharmacists. Retrieved 3 March 2019.
  2. Product Information Clofen. TGA eBusiness Services. Millers Point, Australia: Alphapharm Pty Limited. 7 June 2017. Retrieved 15 August 2017.
  3. Yogeeswari P., Ragavendran J.V., Sriram D. An update on GABA analogs for CNS drug discovery. Recent Patents on CNS Drug Discovery. 2006;1(1):113–118. PMID: 18221197. https://doi.org/10.2174/157488906775245291
  4. Mezler M., Muller T., Raming K. Cloning and functional expression of GABA(B) receptors from Drosophila. Eur J Neurosci. 2001;13(3):477–486. PMID: 11168554. https://doi.org/10.1046/j.1460-9568.2001.01410.x
  5. Carter L.P., Koek W., France C.P. Behavioral analyses of GHB: Receptor mechanisms. Pharmacol Ther. 2008;121(1):100–114. https://doi.org/10.1016/j.pharmthera.2008.10.003
  6. Тагиров А.А., Ларионов С.С. Острые преднамеренные отравления медикаментозным препаратом «Баклофен» у подростков. Успехи современного естествознания. 2014; 6:94. [Tagirov A.A., Larionov S.S. Acute deliberate poisoning with the drug «Baclofen» in adolescents. Uspekhi sovremennogo estestvoznaniya. 2014;6:94. (In Russ.)]
  7. Gablofen (Baclofen). FDA Full Prescribing Information. US Food and Drug Administration. Retrieved 2 January 2016.
  8. Reynaud M., Aubin H.-J., Trinquet F., Zakine B., Dano C., Dematteis M., et al. Arandomized, placebo-controlledstudy of high-dose baclofen in alcohol-dependent patients — the ALPADIR study. Alcohol Alcohol. 2017;52:439–446. PMID: 28525555. https://doi.org/10.1093/alcalc/agx030
  9. Muller C.A., Geisel O., Pelz P., Higl V., Kruger J., Stickel A., et al High-dose baclofen for the treatment of alcohol dependence (BACLAD study): a randomized, placebo-controlled trial. Eur Neuropsychopharmacol. 2015;25:1167–1177. PMID: 26048580. https://doi.org/10.1016/j.euroneuro.2015.04.002
  10. Rigal L., Legay Hoang L., Alexandre-Dubroeucq C., Pinot J., Le Jeunne C., Jaury P. Tolerability of high-dose baclofen in the treatment of patients with alcohol disorders: a retrospective study. Alcohol Alcohol. 2015;50:551–557. https://doi.org/10.1093/alcalc/agv052
  11. Vourc’h M., Feuillet F., Mahe P.-J., Sebille V., Asehnoune K., BACLOREA trial group. Baclofen to Prevent Agitation in Alcohol-Addicted Patients in the ICU: Study Protocol for a Randomised Controlled Trial. Trials. 2016;17(1):415. PMID: 27542731. https://doi.org/10.1186/s13063-016-1539-2
  12. Girish K., Vikram R.K., Pandit L.V., Pundarikaksha H.P., Vijendra R., Vasundara K., et al. A randomized, open-label, standard controlled, parallel group study of efficacy and safety of baclofen, and chlordiazepoxide in uncomplicated alcohol withdrawal syndrome. Biomed J. 2016;39(1):72–80. PMID: 27105601. https://doi.org/10.1016/j.bj.2015.09.002
  13. Beraha E.M., Salemink E., Goudriaan A.E., Bakker A., de Jong D., Smits N., et al. Efficacy and safety of highdose baclofen for the treatment of alcohol dependence: A multicentre, randomised, double-blind controlled trial. European Neuropsychopharmacology. 26(12):1950–1959. PMID: 27842939. https://doi.org/10.1016/j.euroneuro.2016.10.006
  14. Dixit D., Endicott J., Burry L., Ramos L., Yeung S.Y.A., Devabhakthuni S., et al. Management of Acute Alcohol Withdrawal Syndrome in Critically Ill Patients. Pharmacotherapy. 2016;36(7):797–822. PMID: 27196747. https://doi.org/10.1002/phar.1770
  15. Minozzi S., Saulle R., Rosner S. Baclofen for alcohol use disorder. Cochrane Database Syst Rev. 2018;11:CD012557. PMID: 30484285. https://doi.org/10.1002/14651858.CD012557.pub2
  16. van den Brink W. Baclofen: A Game Changer in the Treatment of Alcohol Dependence. Alcohol Alcohol. 2020 Feb 7;55(1): 46–47. PMID: 32031207. https://doi.org/10.1093/alcalc/agz085
  17. McLaughlin M.J., He Y., Brunstrom-Hernandez J., Thio L.L., Carleton B.C., Ross C.J.D., et al. Response in Children With Cerebral Palsy. PM and R. 2018;10(3):235–243. https://doi.org/10.1016/j.pmrj.2017.08.441
  18. Navarrete-Opazo A.A., Gonzalez W., Nahuelhual P. Effectiveness of Oral Baclofen in the Treatment of Spasticity in Children and Adolescents with Cerebral Palsy. Arch Phys Med Rehabil. 2016;97(4):604–618. PMID: 26321489. https://doi.org/10.1016/j.apmr.2015.08.417
  19. Ostermann M.E., Young B., Sibbald W.J., Nicole M.W. Coma mimicking brain death following baclofen overdose. Intensive Care Med. 2000;26:1144–1146. PMID: 11030173. https://doi.org/10.1007/s001340051330
  20. Roberge R.J., Martin T.G., Hodgman M., Benitez J.G., Brunswick J.E. Supraventricular tachyarrhythmia associated with baclofen overdose. Clin Toxil. 1994;32:291–297. PMID: 8007036. https://doi.org/10.3109/15563659409017961
  21. Katyal R., Samkutty D., Muzammil S.M., Saucedo S. Baclofen toxicity presenting as myoclonic status epilepticus. Neurol Clin Pract. 2019 Dec; 9(6):516–518. PMID: 32042496. https://doi.org/10.1212/CPJ.0000000000000686
  22. Rolland B., Deheul S., Danel T., Bordet R., Cottencin O. A case of de novo seizures following a probable interaction of high-dose baclofen with alcohol. Alcohol Alcohol. 2012;47(5): 577–580. PMID: 22753796. https://doi.org/10.1093/alcalc/ags076
  23. de Witte L. D., Dekker D., Veraart J., Kromkamp M., Kaasjager K. Aggression and Restlessness Following Baclofen Overdose: The Narrow Line Between Intoxication and Withdrawal Symptoms. Ned Tijdschr Geneeskd. 2016;160:A9604. PMID: 27484417. (In Dutch)
  24. Wolf M.E., Mosnaim A.D. Baclofen-induced manic symptoms: case report and systematic review. Psychosomatics. 2017;58:94. https://doi.org/10.1016/j.psym.2016.08.004
  25. Chapman R.W., Hey J.A., Rizzo C.A., Bolser D.C. GABAB receptors in the lung. Trendsin Pharmacological Sciences. 1993; 14(1):26–29. PMID: 8382886.
  26. Mizuta K., Xu D., Pan Y., Comas G., Sonett J.R., Zhang Y., et al. GABAA receptors are expressed and facilitate relaxation in airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2008;294(6):L1206–1216. PMID: 18408071.
  27. Denora N., Laquintana V., Lopedota A., Serra M., Dazzi L., Biggio G., et al. Novel L-Dopa and dopamine prodrugs containing a 2-phenyl-imidazopyridine moiety. Pharm Res. 2007; 24(7):1309–1324. PMID: 17404814.

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版权所有 © Romanova O.L., Sundukov D.V., Golubev A.M., Blagonravov M.L., Ershov A.V., 2020

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