COVID-19 pathology: experience of 2000 autopsies
- Authors: Zayratyants O.V.1,2,3, Samsonova M.V.4, Cherniaev A.L.3,4, Mishnev O.D.5, Mikhaleva L.M.3,6, Krupnov N.M.7, Kalinin D.V.8
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Affiliations:
- «A.I. Evdokimov Moscow State University of Medicine and Dentistry» Ministry of Health of Russian Federation
- The State Budgetary Healthcare Institution of Moscow Area Moscows regional research clinical institute n.a. M.F. Vladimirskiy
- Research Institute of Human Morphology
- Federal State Budgetary Institution «Pulmonology Scientific Research Institute under Federal Medical and Biological Agency of Russsian Federation»
- ФГАОУ ВО «Российский национальный исследовательский медицинский университет имени Н.И. Пирогова» Минздрава России
- City Clinical Hospital No. 31
- State Budgetary Institution «D.I. Mastbaum Forensic Medical Bureau»
- Federal State Budget Scientific Research Center «A.V. Vishnevsky Institute of Surgery» of the Ministry of Health of Russian Federation
- Issue: Vol 6, No 4 (2020)
- Pages: 10-23
- Section: ORIGINAL STUDY ARTICLES
- URL: https://journals.rcsi.science/2411-8729/article/view/122396
- DOI: https://doi.org/10.19048/fm340
- ID: 122396
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Abstract
Background: Pathological anatomy, patogenesis and the morphogenesis of manifestations and complications of COVID-19 remain insufficiently studied. The fullest information on structural bases of organs and tissues alterations by new coronavirus disease can be obtained as a result of autopsies.
Aims: The aim of the study was to study the morphological changes of lungs and other organs of the autopsies of COVID-19 deceased persons. Results of 2000 autopsies of people who died of a severe form of COVID-19 in Moscow, consisting of 1212 men and 788 women, from March 20 to May 22, 2020 (a ratio 1.54:1) aged from 20 to 99 years (on average 68.5±15.63 years) were presented. This experience was previously generalized in the Atlas COVID-19 pathology. Autopsies were made in the converted interstationary pathoanatomical offices at strict observance of rules of biosafety according to standard and legal documents of WHO, Russian Ministry of Health and Rospotrebnadzor.
Results: Morphological changes of lungs with varying severity and extent were detected in all examined cases; however, damage to other organs was also common, which in some cases prevailed over pulmonary changes and was the cause of death. The main morphological changes in lungs were diffuse alveolar damage and microangiopathy, alveolar hemorrhage syndrome, thrombosis, and thromboembolism.
Conclusion: The involvement of the lungs, other organs, and vascular system in the pathological process is a result of multiple factors. It is advisable to implement clinical and morphological «masks» of COVID-19.
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##article.viewOnOriginalSite##About the authors
Oleg V. Zayratyants
«A.I. Evdokimov Moscow State University of Medicine and Dentistry» Ministry of Health of Russian Federation; The State Budgetary Healthcare Institution of Moscow Area Moscows regional research clinical institute n.a. M.F. Vladimirskiy; Research Institute of Human Morphology
Author for correspondence.
Email: ovzair@mail.ru
ORCID iD: 0000-0003-3606-3823
Dr. Sci. Med., professor
Russian Federation, 20/1 Delegatskaya street, 127473, Moscow; Moscow; MoscowMaria V. Samsonova
Federal State Budgetary Institution «Pulmonology Scientific Research Institute under Federal Medical and Biological Agency of Russsian Federation»
Email: samary@mail.ru
ORCID iD: 0000-0001-8170-1260
SPIN-code: 9525-9085
Dr. Sci. Med.
Russian Federation, MoscowAndrey L. Cherniaev
Research Institute of Human Morphology; Federal State Budgetary Institution «Pulmonology Scientific Research Institute under Federal Medical and Biological Agency of Russsian Federation»
Email: cheral12@gmail.com
ORCID iD: 0000-0003-0973-9250
Dr. Sci. Med., Professor
Russian Federation, Moscow; MoscowOleko D. Mishnev
ФГАОУ ВО «Российский национальный исследовательский медицинский университет имени Н.И. Пирогова» Минздрава России
Email: mishnevod@gmail.com
ORCID iD: 0000-0002-6466-9147
Dr. Sci. Med., Professor
Russian Federation, МоскваLiudmila M. Mikhaleva
Research Institute of Human Morphology; City Clinical Hospital No. 31
Email: mikhalevalm@yandex.ru
ORCID iD: 0000-0003-2052-914X
SPIN-code: 2086-7513
Dr. Sci. Med., Professor
Russian Federation, Moscow; MoscowNikolai M. Krupnov
State Budgetary Institution «D.I. Mastbaum Forensic Medical Bureau»
Email: Krupatan@yandex.ru
ORCID iD: 0000-0002-5162-1662
SPIN-code: 4814-3226
Cand. Sci. (Med.)
Russian Federation, RyazanDmitry V. Kalinin
Federal State Budget Scientific Research Center «A.V. Vishnevsky Institute of Surgery» of the Ministry of Health of Russian Federation
Email: dmitry.v.kalinin@gmail.com
ORCID iD: 0000-0001-6247-9481
Cand. Sci. (Med.)
Russian Federation, MoscowReferences
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