Prospects for studying the thanatogenesis and morphological manifestations of alcoholic cardiomyopathy
- Authors: Kulbitskiy B.N.1,2, Dzhuvalyakov P.G.1, Bogomolov D.V.1, Sundukov D.V.2, Fedulova M.V.3, Kutsenko K.I.4
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Affiliations:
- Research Institute of Human Morphology
- Peoples’ Friendship University of Russia
- Russian Centre of Forensic Medical Expertise
- The International Law Institute
- Issue: Vol 8, No 1 (2022)
- Pages: 59-66
- Section: REVIEWS
- URL: https://journals.rcsi.science/2411-8729/article/view/122455
- DOI: https://doi.org/10.17816/fm418
- ID: 122455
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Abstract
The purpose of the work was to analyze the current literature data on the morphology and thanatogenesis of alcoholic cardiomyopathy, as well as to determine further prospects for research on this issue. Domestic and foreign literary sources devoted to sudden death, pathomorphology of alcoholic cardiomyopathy, immunohistochemical and biochemical methods of its diagnosis were studied. As a result of the analysis, the essence of thanatogenesis in alcoholic cardiomyopathy is revealed, the prospect of immunohistochemical and morphometric methods is outlined.
According to the literature data, based on the results of the studies, an approximate scheme of thanatogenesis and subsequent scientific directions for the study of investigative deaths in alcoholic cardiomyopathy, in search of other diseases, can be built. In the Australian literature, the benefits of immunohistochemical are used to elucidate the antecedent pathochemical consequences. Also, in relation to the diagnosis of death from alcoholic cardiomyopathy, thanatogenetic analysis can be provided, since the sequence of development of fatally significant events in the form of various sudden deaths is not the same. In the interpretation of the processes occurring at the end of thanatogenesis in the myocardium, polarization microscopic examination is indispensable. I would like to note a number of biochemical changes in alcoholic cardiomyopathy, which demonstrate some features of the course of metabolic processes in this pathology, especially since this method and the immunohistochemical study are more in line with the modern requirements of evidence-based medicine.
As a result of the literature analysis, the essence of thanatogenesis in alcoholic cardiomyopathy was revealed, the prospect of immunohistochemical and morphometric methods was outlined.
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##article.viewOnOriginalSite##About the authors
Boris N. Kulbitskiy
Research Institute of Human Morphology; Peoples’ Friendship University of Russia
Author for correspondence.
Email: kulbitskiybn@mail.ru
ORCID iD: 0000-0001-7791-3041
SPIN-code: 7785-0838
Scopus Author ID: 777044
MD, Senior Research Associate
Russian Federation, 3 Tsyurupy str., Moscow, 125284; MoscowPavel G. Dzhuvalyakov
Research Institute of Human Morphology
Email: fred197490@gmail.com
ORCID iD: 0000-0003-1709-2418
SPIN-code: 5925-7780
MD, Dr. Sci. (Med.)
Russian Federation, 3 Tsyurupy str., Moscow, 125284Dmitry V. Bogomolov
Research Institute of Human Morphology
Email: usicc@yandex.ru
ORCID iD: 0000-0002-9111-8623
SPIN-code: 2777-2674
MD, Dr. Sci. (Med.), Senior Research Associate
Russian Federation, 3 Tsyurupy str., Moscow, 125284Dmitry V. Sundukov
Peoples’ Friendship University of Russia
Email: sudmed.rudn@yandex.ru
ORCID iD: 0000-0001-8173-8944
SPIN-code: 2968-7961
MD, Dr. Sci. (Med.), Assistant Professor
Russian Federation, 3 Tsyurupy str., Moscow, 125284Maria V. Fedulova
Russian Centre of Forensic Medical Expertise
Email: marfedul@rambler.ru
ORCID iD: 0000-0002-8787-2228
SPIN-code: 5382-2170
MD, Dr. Sci. (Med.)
Russian Federation, 3 Tsyurupy str., Moscow, 125284Kirill I. Kutsenko
The International Law Institute
Email: ceamler@gmail.com
ORCID iD: 0000-0001-9299-5153
SPIN-code: 8964-3717
MD, Cand. Sci. (Med.), Assistant Professor
Russian Federation, 3 Tsyurupy str., Moscow, 125284References
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