Pathology of COVID-19
- Authors: Sagidullin R.H.1, Khalikov A.A.1, Nazmieva A.R.1, Kuznetsov K.O.2, Kartoeva H.V.1
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Affiliations:
- Bashkir State Medical University
- The Russian National Research Medical University named after N.I. Pirogov
- Issue: Vol 8, No 1 (2022)
- Pages: 41-50
- Section: REVIEWS
- URL: https://journals.rcsi.science/2411-8729/article/view/122448
- DOI: https://doi.org/10.17816/fm421
- ID: 122448
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Abstract
Coronavirus infection 2019 (COVID-19) has become a challenge for the health care system around the world due to the progressive increase in the number of cases with severe manifestations of the disease. Autopsy findings are fundamental and critical to better understanding how infection affects the human body. These data are needed to improve diagnostic and treatment methods, as well as to stratify risk groups.
The purpose of the review is to analyze and summarize the pathological data available to date related to COVID-19. In COVID-19, the lungs are usually severe and swollen. Histologically, the most frequent is the detection of both exudative and proliferative diffuse alveolar injury with the formation of hyaline membranes, inflammatory cell infiltration, and stagnant small vessels. There is also evidence that SARS-CoV-2 causes endothelial dysfunction. There is still insufficient data to reflect the complete pathophysiological picture of SARS-CoV-2 infection.
Almost all of the articles reviewed in this review focused on pulmonary macro- and microscopic changes; there is little data on the features of the virus affecting other organs and its systemic effect. Despite the tremendous attention and investment in the fight against the new coronavirus infection, diagnosis of most of the deaths associated with COVID-19 is difficult.
It is necessary to conduct further pathological studies, the purpose of which should be the development of a standardized diagnostic method, as well as the isolation of pathognomonic signs of the disease.
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##article.viewOnOriginalSite##About the authors
Rafael H. Sagidullin
Bashkir State Medical University
Email: sagidullin12@yandex.ru
ORCID iD: 0000-0002-5721-8831
MD, Cand. Sci. (Med.), Associate Professor
Russian Federation, UfaAirat A. Khalikov
Bashkir State Medical University
Email: airat.expert@mail.ru
ORCID iD: 0000-0003-1045-5677
SPIN-code: 1895-7300
MD, Dr. Sci. (Med.), Professor
Russian Federation, UfaAlina R. Nazmieva
Bashkir State Medical University
Email: nazmieva12@mail.ru
ORCID iD: 0000-0002-7653-9585
Russian Federation, Ufa
Kirill O. Kuznetsov
The Russian National Research Medical University named after N.I. Pirogov
Email: kirillkuznetsov@aol.com
ORCID iD: 0000-0002-2405-1801
SPIN-code: 3053-3773
Russian Federation, per. Holzunova 7, 119435, Moscow
Hyadi V. Kartoeva
Bashkir State Medical University
Author for correspondence.
Email: kartoeva97@inbox.ru
ORCID iD: 0000-0002-4364-272X
Russian Federation, Ufa
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