The level of chromosome aberrations and the activity of chromosomes' kernel-forming areas in the Kursk region

The aim of the research is the study of the regularity of the phenotypic manifestation of the level of chromosome aberrations and of the transcriptional activity of chromosomes' kernel-forming areas on the example of arterial hypertension development. The obtained results proved the influence of the activity of the kernel-forming chromosomes' areas and the formation of chromosome aberrations on the development of the arterial hypertension in people.It was demonstrated for the first time that people with high transcriptional activity of chromosomes' kernel-forming areas have the lowest level of chromosome aberrations, which is explained by a high proliferative activity of this group and by a more intensive protein synthesis (including reparation proteins). The data on adaptive significance of chromatid chromosome destructions holding back the development of the arterial hypertension have been obtained. Thus, the interrelation between functional Ag-polymorphism and the level of chromosome aberrations during the development of arterial hypertension in people has been established, linear dependence being absent between these two characteristics.

Chromosome aberrations, chromosomes kernel-forming areas, Kursk region, Ag-polymorphism, arterial hypertension