Genetic factors for development thrombophilia in pregnant
- Authors: Bondar TP1, Muratova AY1
-
Affiliations:
- Stavropol State University
- Issue: No 1 (2012)
- Pages: 119-120
- Section: Articles
- URL: https://journals.rcsi.science/2313-0245/article/view/338279
- ID: 338279
Cite item
Full Text
Abstract
The results of studying the frequency of genetic polymorphism of receptor subunits platelet GP IIb/IIIa in 408 pregnant women.
It was found that in women with thrombophilia normal variant of the gene occurred in 63.6%, heterozygous mutation - in 21%, homozygous mutation - in 15,2% of cases. In healthy women heterozygous mutation was revealed in 15,7%, normal genotype - in 84,3% and homozygous mutations was not detected at all. The connection between the occurrence of clinical manifestations of thrombophilia and the presence of hetero- and homozygous mutations of the subunits of platelet receptor GP IIb/IIIa was shown.
It was found that in women with thrombophilia normal variant of the gene occurred in 63.6%, heterozygous mutation - in 21%, homozygous mutation - in 15,2% of cases. In healthy women heterozygous mutation was revealed in 15,7%, normal genotype - in 84,3% and homozygous mutations was not detected at all. The connection between the occurrence of clinical manifestations of thrombophilia and the presence of hetero- and homozygous mutations of the subunits of platelet receptor GP IIb/IIIa was shown.
About the authors
T P Bondar
Stavropol State University
Email: sonu@live.ru
Кафедра физико-химических основ медицины,лабораторной диагностики и фармакологииМедико-биолого-химический факультет; Ставропольский государственный университет; Stavropol State University
A Y Muratova
Stavropol State University
Email: sonu@live.ru
Кафедра физико-химических основ медицины,лабораторной диагностики и фармакологииМедико-биолого-химический факультет; Ставропольский государственный университет; Stavropol State University
Supplementary files
