Meningococcal vaccine. From capsular polysaccharides of microbes to proteases

A P Alliluyev; Аллилуев Александр Павлович; I V Anokhina; Анохина Ирина Викторовна; L D Rumsh; Румш Л Д; E E Melnikov; Мельников Э Э; O V Kotelnikova; Котельникова О В; E A Sitnikova; Ситникова Е А; E J Drozzina; Дрожжина Е Ю; L S Zhigis; Жигис Л С; E J Yagudayeva; Ягудаева Е Ю; O A Razgulyaeva; Разгуляева О А; V S Zueva; Зуева В С; L V Kozlov; Козлов Л В; A E Avakov; Аваков А Э

Meningococcal vaccine. From capsular polysaccharides of microbes to proteases

Authors: Alliluyev AP¹, Anokhina IV¹, Rumsh LD², Melnikov EE², Kotelnikova OV², Sitnikova EA², Drozzina EJ², Zhigis LS², Yagudayeva EJ², Razgulyaeva OA², Zueva VS², Kozlov LV³, Avakov AE⁴
Affiliations:
1. People’s Friendship University
2. Institute of bioorganic chemistry n. a. M.M. Shemyakin and Yu. A. Ovchinnikov of the Russian Academy of Sciences
3. ederal budgetary institution of science Moscow Research Institute of Epidemiology and Microbiology n. a. G.N. Gabrichevskiy
4. Ltd. “Bio-Diagnostics”
Issue: No 4 (2012)
Pages: 16-22
Section: Articles
URL: https://journals.rcsi.science/2313-0245/article/view/338185
ID: 338185

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Abstract

Microbial capsular polysaccharides for many years provided a highly practical public health vaccines for preventing meningococcal, pneumococcal and Haemophilus influenza infection, and typhoid fever. Their application in the form of conjugates with protein carriers eliminate the gap in protection against these infections in children under one year. Extremely promising turned out offered us a new generation of vaccines, which have synthetic peptides conjugated to a meningococcal polysaccharide. Thus, new approaches to the solution of the problem of meningococcal disease vaccination serogroup B were open. In recent years, Russian researchers first suggested to use IgA1 protease (one of the major virulence factors of microbes and almost identical for mentioned below infections) for prevention of such diseases as meningococcal of all serogroups, pneumococcus and hemophilia infections. Patented processes for producing of the vaccine define domestic priority of its production and use.

Keywords

meningitis, polysaccharide, vaccine, IgA1 protease

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Meningococcal vaccine. From capsular polysaccharides of microbes to proteases

Full Text

Abstract

Keywords

About the authors

Supplementary files