Meningococcal polyvaccine on the basis of cleared IgAI protease

A P Alliluev; Аллилуев А П; I V Anohina; Анохина И В; L D Rumsh; Румш Л Д; O V Kotelnikova; Котельникова О В; E Yu Drozzina; Дрожжина Е Ю; L S Zhigis; Жигис Л С; E Yu Yagudaeva; Ягудаева Е Ю; O A Razgulyaeva; Разгуляева О А; S S Zueva; Зуева В С; L V Kozlov; Козлов Л В; A M Bichucher; Бичучер А М; A E Avakov; Аваков А Э

Meningococcal polyvaccine on the basis of cleared IgAI protease

Authors: Alliluev AP¹, Anohina IV¹, Rumsh LD², Kotelnikova OV², Drozzina EY.², Zhigis LS², Yagudaeva EY.², Razgulyaeva OA², Zueva SS², Kozlov LV³, Bichucher AM³, Avakov AE⁴
Affiliations:
1. 'Peoples Friendship University of Russia
2. M.M. Shemyakin & Yu.A. Ovchinnikov Instituteof Bioorganic Chemistry, Russian Academy of Sciences
3. G.N. Gabrichevsky Moscow Research Instituteof Epidemiology and Microbiology of Russia
4. The branch of the federal state unitary enterpriseResearch-and-production association «Microgene» G.N. GabrichevskyThe enterprise for manufacture bacterial preparations
Issue: No 1 (2010)
Pages: 7-12
Section: Articles
URL: https://journals.rcsi.science/2313-0245/article/view/337730
ID: 337730

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Abstract

IgA1-protease allocated from the culture N. meningitidis serogroup A. As original materials were used three different intermediate products of vaccine production: cultural fluid, cetavlon supernatant and cetavlon precipitate. IgA1-protease was used to evaluate their protectivity and immunogenity. It was shown, that isolated IgA1 protease from the meningococcus serogroup A is able to protect mice, infected by meningococcus serogroup B.

Keywords

IgA1 protease, meningococcus, immunogenity, protection, polyvaccina

About the authors

A P Alliluev

'Peoples Friendship University of Russia <http://www.multitran.ru/c/m.exe?t=4557871_1_2>

Email: alliluevap@mail.ru <mailto:alliluevap@mail.ru>
Кафедра микробиологииМедицинский факультет; Российский университет дружбы народов; 'Peoples Friendship University of Russia

I V Anohina

'Peoples Friendship University of Russia <http://www.multitran.ru/c/m.exe?t=4557871_1_2>

Кафедра микробиологииМедицинский факультет; Российский университет дружбы народов; 'Peoples Friendship University of Russia