The peculiarities of parametrical changes of free radical oxidation, endogenic intoxication and liver condition at treatment of dysfunctional uterine bleeding with progesteron and utrogestan

Peculiarities of changes in free radical oxidation, endogenic intoxication and functional condition of liver were studied in patients with dysfunctional uterine bleeding at treatment with Progesteron and Utrogestan. It is shown that the level of free radical oxidation increases and the activity of antioxidant protection decreases on the background of elevated endogenic intoxication. It is accompanied by decrease of the liver protein synthetical function and increase activity of tracer enzymes - cytolyses markers. Progesteron increases endogenic intoxication and hypoalbuminemia on the background of increased activity of peroxide lipids oxidation in case of initial liver's function disorder. Utrogestan increases hypoalbuminemia on the background of increased activity of tracer enzymes along with decreased intensivity of peroxide lipids oxidation and preservation of depression of antioxidatic protection and endointoxication. These changes are necessary for considering at treatment planning.

free radical oxidation, endogenic intoxication, Progesteron, Utrogestan, liver functional condition