Development of structure and technology of wound healthing gel

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Abstract

Carbopol (974 P) was selected as the structure former to make a gel with L-lysine-alpha oxidase. Stability of the gel developed was studied with the use of physico-chemical, rheological and microbiological methods of analysis for the following indicators: the appearance of the gel, odor, pH, uniformity, colloid stability. The authenticity of the activity of L-lysine-a-oxidase in the gel, the viscosity of the gel and microbiological purity of the project comply with manufacturer's monograph L-Lysine-a-oxidase gel, 1% concentration. Studied the specific activity of the developed gel in animal experiments. The results of this study suggest a high wound-healing activity of gel with extract of L-lysine alpha-oxidase of 1%.

About the authors

O A Semkina

Peoples’ Friendship University of Russia

Email: semkina@med.rudn.ru
Department of the general pharmaceutical and biomedical technology; All-Russian Institute of Medicinal and Aromatic Plants Grina str., 7, Moscow, Russia, 117216

I P Smirnova

Peoples’ Friendship University of Russia

Department of biochemistry

M A Dzhavakhyan

All-Russian Institute of Medicinal and Aromatic Plants

O V Bondarenko

All-Russian Institute of Medicinal and Aromatic Plants

Email: riska.86@mail.ru

L M Kishmakhova

Peoples’ Friendship University of Russia

Department of the general pharmaceutical and biomedical technology

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