The level of c-type natriuretic peptide in patients with respiratory cardial comorbidity, depending on genotypes of the gene of endothelial nitric oxide synthase

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Abstract

In this work we have studied the level of C-type natriuretic peptide in patients with respiratory cardiac comorbidities (COPD + HD, COPD + IHD), depending on the genotypes (4a/4b and 4b/4b) of the gene of endothelial nitric oxide synthase. Investigation revealed the influence of VNTR-polymorphism on the level of CNUP under the comorbidity combination of COPD + HD, significantly increased production of CNUP, compared with a single disease. At the same time, in patients with COPD + IHD combination of 4а/4b has no significant effect on CNUP production, which is comparable with a single disease (COPD, IHD).

About the authors

O S Polunina

Astrakhan State Medical Academy

Email: admed@yandex.ru
Department of internal medicine of the pediatric faculty State Budgetary Educational Institution of Higher Professional Education

A Kh Akhmineeva

Astrakhan State Medical Academy

Email: aaziza@mail.ru
Department of internal medicine of the pediatric faculty State Budgetary Educational Institution of Higher Professional Education

I V Sevostyanova

Astrakhan State Medical Academy

Email: irina-nurzhanova@yandex.ru
Department of internal medicine of the pediatric faculty State Budgetary Educational Institution of Higher Professional Education

L P Voronina

Astrakhan State Medical Academy

Email: voroninaluda74@mail.ru
Department of internal medicine of the pediatric faculty State Budgetary Educational Institution of Higher Professional Education

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