The mechanism of immunosuppression in patients with brain glioma

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Abstract

The activity of diamineoxydase and polyamineoxydase which were synthesized by blood cells in the culture medium during the transformation of lymphocytes in the blasts when exposed to various dilutions of phytohemagglutinin have been determined in patients with cerebral gliomas of different degree of malignancy. Under these conditions, the degree of aggregation of blood cells was determined by new highly sensitive method of surface plasmon resonance. Increased activity of diamineoxydase and polyamineoxydase in spinal hernias and decreased activity of these enzymes in malignant gliomas has been found. The regulatory role of these enzymes in the processes of lymphocyte proliferative activity in neurosurgical pathology, including brain gliomas of different degree of malignancy, is suggested.

About the authors

V A Frolov

Peoples’ Friendship University of Russia

Email: frolov@med.rudn.ru
Кафедра общей патологии и патологической физиологии

S P Syatkin

Peoples’ Friendship University of Russia

Email: syata@mail.ru
Кафедра биохимии

N Ya Gridina

State Institution “Institute of Neurosurgery of the Ukrainian NAMS”

Email: gridinanina@ukr.net
Лаборатория экспериментальной нейрохирургии

N G Draguntsova

State Institution “Institute of Neurosurgery of the Ukrainian NAMS”

Email: zfaust@e-mail.ua
Лаборатория экспериментальной нейрохирургии

O I Veselova

State Institution “Institute of Neurosurgery of the Ukrainian NAMS”

Email: syata@mail.ru
Лаборатория экспериментальной нейрохирургии

V P Chunikhin

Institute of Biochemistry n.a. A.V. Palladin of the Ukrainian NAS

Email: alchun@ukr.net
Laboratory of optical methods for studying

A Yu Maslov

Lashkarev Institute of semiconducter physics of the Ukrainian NAS

Email: vladmaslov@mail.ru
Отдел физико-технологических основ сенсорного материаловедения

Yu V Ushenin

Lashkarev Institute of semiconducter physics of the Ukrainian NAS

Email: ushyury@mail.ru
Отдел физико-технологических основ сенсорного материаловедения

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