Prooxidant-antioxidant control of the effectiveness of aerosol therapy for acute catarrhal bronchopneumonia in calves
- Authors: Kulikov E.V.1, Sotnikova E.D.1, Rodionova N.Y.1, Prozorovskiy I.E.1, Shepeleva K.V.1, Rudenko P.A.1
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Affiliations:
- RUDN University
- Issue: Vol 20, No 2 (2025): Applied aspects of pharmaceutical science in veterinary medicine
- Pages: 214-226
- Section: Applied aspects of pharmaceutical science in veterinary medicine
- URL: https://journals.rcsi.science/2312-797X/article/view/315843
- DOI: https://doi.org/10.22363/2312-797X-2025-20-2-214-226
- EDN: https://elibrary.ru/MRPDMW
- ID: 315843
Cite item
Abstract
The results of prooxidant-antioxidant control of the efficiency of various schemes of aerosol complex therapy for acute catarrhal bronchopneumonia in calves using the generally accepted scheme (aerosol treatment indoors with iodotriethyleneglycol solution with intramuscular administration of the drug ”Penstrep‑400“), as well as schemes proposed by us, based on previously conducted studies to determine the sensitivity of isolated microflora to antibacterial drugs (aerosol treatment indoors with iodotriethyleneglycol solution with intramuscular administration of the drug ”Marfloxacin“) and phytobiotics (aerosol treatment indoors with Hypericum perforatum wort extract with intramuscular administration of the drug ”Marfloxacin“) were presented. Black-and-white calves, aged 1–3 months, mixed sex, with clinical signs of acute catarrhal bronchopneumonia were studied. The sick animals were divided into three experimental groups using the envelope method: 1O — experimental 1, n = 20; 2O — experimental group 2, n = 20 and 3O — experimental group 3, n = 20 and placed in separate isolators. During the treatment of animals in group 1O, the general clinical improvement occurred only on the 9.25 ± 0.91 day, while six cases of complications occurred, and two animals died. The treatment of calves in group 2O was accompanied by the general clinical improvement 2.05 days earlier, compared with group 1O, and all animals recovered. Therapy in group 3O contributed to the general clinical improvement already on the 4.90 ± 0.64 day, which is 47.0% earlier compared with the indicators of group 1O, and all 20 calves also recovered. The study of the processes of lipid peroxidation and antioxidant protection in blood plasma of experimental calves in the dynamics of treatment confirmed the best result in 3O group, which was accompanied by a significant decrease in LPO products and an increase in AOS indicators, which already on the 7th day of observation approached the physiological norm.
About the authors
Evgeniy V. Kulikov
RUDN University
Email: kulikov-ev@rudn.ru
ORCID iD: 0000-0001-6936-2163
SPIN-code: 6199-2479
Candidate of Biological Sciences, Associate Professor, Agrarian and Technological Institute
6 Miklukho-Maklaya st., Moscow, 117198, Russian FederationElena D. Sotnikova
RUDN University
Email: sotnikova-ed@rudn.ru
ORCID iD: 0000-0003-1253-1573
SPIN-code: 5511-3661
Candidate of Biological Sciences, Associate Professor, Agrarian and Technological Institute
6 Miklukho-Maklaya st., Moscow, 117198, Russian FederationNatalya Y. Rodionova
RUDN University
Email: rodionova-nyu@rudn.ru
ORCID iD: 0000-0002-8728-2594
SPIN-code: 8032-5437
Assistant, Department of Veterinary Medicine, Agrarian and Technological Institute
6 Miklukho-Maklaya st., Moscow, 117198, Russian FederationIvan E. Prozorovskiy
RUDN University
Email: prozorovskiy-ie@rudn.ru
ORCID iD: 0000-0002-1849-3849
SPIN-code: 3099-3960
Assistant, Department of Veterinary Medicine, Agrarian and Technological Institute
6 Miklukho-Maklaya st., Moscow, 117198, Russian FederationKristina V. Shepeleva
RUDN University
Email: shepeleva-kv@rudn.ru
ORCID iD: 0000-0002-1105-2602
SPIN-code: 8955-6199
Assistant, Department of Veterinary Medicine, Agrarian and Technological Institute
6 Miklukho-Maklaya st., Moscow, 117198, Russian FederationPavel A. Rudenko
RUDN University
Author for correspondence.
Email: rudenko-pa@rudn.ru
ORCID iD: 0000-0002-0418-9918
SPIN-code: 4883-1758
Doctor of Veterinary Sciences, Professor, Department of Veterinary Medicine, Agrarian and Technological Institute,
6 Miklukho-Maklaya st., Moscow, 117198, Russian FederationReferences
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