Email this article Oxidative stress in dogs with cardiorenal syndrome caused by endocardiosis
- Authors: Vatnikov Y.A.1, Rudenko A.A.1,2, Shchurov I.V.1, Vilkovyskiy I.F.1,3, Yarovenko E.M.4
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Affiliations:
- RUDN University
- Russian Biotechnological University (ROSBIOTECH)
- Veterinarnoe zdorovie
- Veterinary Clinic ‘ZooAcademy’
- Issue: Vol 19, No 3 (2024)
- Pages: 497-506
- Section: Veterinary science
- URL: https://journals.rcsi.science/2312-797X/article/view/315803
- DOI: https://doi.org/10.22363/2312-797X-2024-19-3-497-506
- EDN: https://elibrary.ru/CIGQPD
- ID: 315803
Cite item
Abstract
Oxidative stress and decreased antioxidant defense were registered in dogs with endocardiosis. Complication of underlying pathology in the form of cardiorenal syndrome leads to aggravation of lipid peroxidation processes and causes further decrease in activity of enzymes of antioxidant defense system of animal organism. The aim of the study was to evaluate the pathophysiological significance of oxidative stress in the processes of formation and progression of cardiorenal syndrome in dogs with endocardiosis. Concentration of malondialdehyde, ceruloplasmin, diene conjugates, activity of superoxide dismutase, catalase, glutathione reductase, glutathione peroxidase were measured in venous blood serum samples from 24 dogs with uncomplicated forms of endocardiosis, 31 dogs with endocardiosis complicated by cardiorenal syndrome, and 22 healthy dogs. Compared with the group of healthy dogs, dogs with endocardiosis were diagnosed with statistically significantly higher median of serum concentrations of malondialdehyde, ceruloplasmin, diene conjugates, as well as statistically significantly lower activity of superoxide dismutase, catalase, glutathione reductase, glutathione peroxidase, which indicates activation and progression of lipid peroxidation processes against the background of simultaneous decrease in parameters of antioxidant defense system. Presence of cardiorenal syndrome in dogs with endocardiosis led to a sharp increase in manifestations of oxidative stress, which should be considered by clinicians when optimizing therapeutic and preventive measures. Lipid peroxidation products, as well as indicators of enzyme systems of antioxidant defense can be used as potential biomarkers of the development of cardiorenal complications in dogs with endocardiosis.
About the authors
Yuri A. Vatnikov
RUDN University
Author for correspondence.
Email: vatnikov_yu@rudn.ru
ORCID iD: 0000-0003-0036-3402
SPIN-code: 2726-8270
Doctor of Veterinary Sciences, Professor, Director of Department of Veterinary Medicine, Agrarian and Technological Institute
6 Miklukho-Maklaya st., Moscow, 117198, Russian FederationAndrey A. Rudenko
RUDN University; Russian Biotechnological University (ROSBIOTECH)
Email: vetrudek@yandex.ru
ORCID iD: 0000-0002-6434-3497
SPIN-code: 6403-6832
Professor, Department of Veterinary Medicine, Doctor of Veterinary Sciences, Russian Biotechnological University; Department of Veterinary Medicine, Agrarian and Technological Institute, RUDN University
6 Miklukho-Maklaya st., Moscow, 117198, Russian Federation; 11 Volokalamskoye highway, Moscow, 125080, Russian FederationIgor V. Shchurov
RUDN University
Email: shchurov-iv@pfur.ru
ORCID iD: 0009-0001-8319-6680
Candidate of Veterinary Sciences, head of Center for Veterinary Innovative Medicine, Agrarian and Technological Institute
6 Miklukho-Maklaya st., Moscow, 117198, Russian FederationIlia F. Vilkovyskiy
RUDN University; Veterinarnoe zdorovie
Email: med-vet@bk.ru
ORCID iD: 0000-0003-4552-2083
SPIN-code: 6544-1649
Candidate of Veterinary Sciences, Associate Professor, Department of Veterinary Medicine, Agrarian and Technological Institute, RUDN University; Director, ‘Veterinarnoe zdorovie’ company
13 Fizicheskaya st., Troitsk, 108840, Russian FederationEvgenia M. Yarovenko
Veterinary Clinic ‘ZooAcademy’
Email: zooac@yandex.ru
Veterinary doctor 1B Yaltinskaya st., Moscow, 117452, Russian Federation
References
- Ushakova TM, Starikova EA. Pharmacocorrection of oxidative stress in case of hepatic insufficiency in dogs. Izvestia Orenburg State Agrarian University. 2018;(6):166—170. (In Russ.).
- Ushakova TM, Starikova EA. Correction of disturbances in the hepatorenal system in dogs with toxic hepatitis. Izvestia Orenburg State Agrarian University. 2018;(4):250—253. (In Russ.).
- Baranova NV, Rudenko AA, Rudenko PA. Cardiorenal syndrome in dogs with mitral valve endocardiosis. In: Collection of proceedings of the 11th International Interuniversity Conference on Clinical Veterinary Medicine in the Purina Partners format. Moscow; 2021. p.413—420. (In Russ.).
- Letunovskaya AV, Babich PS. Ceruloplasmin in non-inflmammary gland pathologies in female dogs. In: A modern view of the future of science: priority areas and tools for development: conference proceedings. St. Petersburg; 2017. p.12—14. (In Russ.).
- Radchenko AO, Makienko NV, Vodyanitska NA. Multimorbid and polypharmacy in clinical cardiology in terms of the clinical case. The Journal of V.N. Karazin Kharkiv National University. Series “Medicine”. 2017;(33):91—94.
- Babkina TN, Ushakova TM. Correlation of redox homeostasis disorders and metabolic processes in hypothyrosis in dogs. Actual questions of veterinary biology. 2021;(3):37—40. (In Russ.). doi: 10.24412/2074- 5036-2021-3-37-40
- Vatnikov Y, Rudenko A, Gnezdilova L, Sotnikova E. Byakhova V, Piven E, et al. Clinical and diagnostic characteristics of the development of hepatocardial syndrome in black and white cows in the early lactation period. Veterinary World. 2022;15(9):2259—2268. doi: 10.14202/vetworld.2022.2259-2268
- Gaisin IR, Valeeva RM, Maksimov NI. Cardiorenal continuum in hypertensive pregnancy. Arterial Hypertension. 2009;15(5):590—597. (In Russ.).
- Reznik EV, Gendlin GE, Gushchina VM, Storozhakov GI. Chronic kidney disease in chronic heart failure patients. Review. Nephrology and Dialysis. 2010;12(1):13—24. (In Russ.).
- Vishneva EM, Sagadeyeva OA, Vishneva KA. The problem of comorbidity in patients with chronic kidney disease and cardiovascular diseases. Medicus. 2022;(3):24—32. (In Russ.).
- Astashkin EI, Glezer MG, Orekhova NS, Egorova ND, Grachev SV, Sokolova IN. Effect of Actovegin on blood phagocytes under oxidative stress in patients with heart failure. Pharmateka. 2014;(9):14—19. (In Russ.).
- Petyunin PA, Zolotaikina VI, Ananko SY, Lapshina LA. Evaluation of the effect of quercetin on oxidative stress and cardiohemodynamics in the treatment of acute heart failure. International Journal of Applied and Fundamental Research. 2012;(1—1):63. (In Russ.).
- Efendiev AM, Mamedova FI, Azizova GI, Dadashova AR. Prognostic significance of factors of apoptosis and oxidative stress in chronic heart failure. Siberian Medical Journal (Irkutsk). 2018;153(2):13—16. (In Russ.).
- Kostylev VA, Goncharova AV. Echocardiography of dogs with mitral valve pathologies. In: Collection of proceedings of the twelfth International Interuniversity Conference on Clinical Veterinary Medicine in Partners format. Moscow; 2022. p.618—626. (In Russ.).
- Rudenko AA. Serum antimiocardial and antivalvular autoantibodies concentration in dogs with endocardiosis of mitral valve. Russian Veterinary Journal. 2017;(8):10—13. (In Russ.).
- Kondratenko AA. Diagnosis and treatment of atrioventricular valve endocardiosis in dogs. In: Problems of intensive development of animal husbandry and their solution: conference proceedings. Bryansk; 2021. p.229—232. (In Russ.).
- Rudenko AA. Evaluation of sleeping respiratory rate in cats with congestive heart failure: the degree of adherence to this test of animal owners and its impact on patient survival. Russian Veterinary Journal. 2018;(4):9—14. (In Russ.). doi: 10.32416/article_5bd1c1f917fda5.38468318
- Rasskazova EA. Electrocardiographic diagnostics of endocardiosis of atrioventricular valves in dogs. In: Problems of intensive development of animal husbandry and their solution: conference proceedings. Bryansk; 2021. p.327—331. (In Russ.).
- Lukyanov AA, Sadikulova AV. Diagnostics and treatment of endocardiosis in dogs. In: Student science for the anniversary of the university: conference proceedings. Tver; 2022. p. 208—211. (In Russ.).
- Morozov IA, Elizarova TS. Diagnostics of congestive heart failure in dogs with mitral valve endocardiosis. In: Humanitarian, natural science and technical solutions of our time in the context of digitalization: conference proceedings. Rostov-on-Don; 2021. p.88—94. (In Russ.).
- Alerdinsk EG, Samsoenova TS. Diagnostics of atrioventricular valve endocardiosis in dogs. Actual issues of development of agricultural sectors: theory and practice: conference proceedings. Rostov-on-Don — Taganrog; 2020. p.136—141. (In Russ.). doi: 10.34924/FRARС.2020.1.63911
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