Binding of Curcumin to Star Polyoxazolines in Aqueous Solutions

A. N. Blokhin; Блохин А. Н.; N. D. Kozina; Козина Н. Д.; A. B. Razina; Разина А. Б.; A. V. Tenkovtsev; Теньковцев А. В.

doi:10.31857/S2308112023700293

Binding of Curcumin to Star Polyoxazolines in Aqueous Solutions

Autores: Blokhin A.N.¹, Kozina N.D.¹, Razina A.B.¹, Tenkovtsev A.V.¹
Afiliações:
1. Institute of Macromolecular Compounds, Russian Academy of Sciences
Edição: Volume 65, Nº 1 (2023)
Páginas: 27-31
Seção: СТРУКТУРА И СВОЙСТВА
URL: https://journals.rcsi.science/2308-1120/article/view/135330
DOI: https://doi.org/10.31857/S2308112023700293
EDN: https://elibrary.ru/UYWBLS
ID: 135330

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Resumo

The binding of the biologically active natural dye curcumin by star-shaped poly-2-alkyl-2-oxazolines of various structures in an aqueous medium has been studied by spectrophotometry in the ultraviolet and visible regions. The objects of study were synthesized and previously described four- and eight-armed star-shaped poly-2-alkyl-2-oxazolines with calixarene central units. The Benesi–Hildebrand method was used to determine the binding constants of dye molecules by polymer micelles. The results obtained demonstrate highly efficient binding of curcumin by polymer macromolecules and micelles in aqueous solutions. It has been shown that the efficiency of curcumin binding by star polyoxazolines is determined to a greater extent by the structure of the hydrophobic calixarene central unit, rather than the nature of polyoxazoline arms.

Bibliografia

Goel A., Kunnumakkara A.B., Aggarwal B.B. // Biochem. Pharmacol. 2008. V. 75. P. 787.
Xu P.H., Long Y., Dai F., Liu Z.L. // Vasc. Pharmacol. 2007. V. 47. P. 25.
Zorofchian Moghadamtousi S., Abdul Kadir H., Hassandarvish P., Tajik H., Abubakar S., Zandi K. // BioMed Res. Int. 2014. V. 2014. P. 186864.
Jagetia G.C., Aggarwal B.B. // J. Clin. Immunol. 2007. V. 27. P. 19.
Shin G.H., Li J., Cho J.H., Kim J.T., Park H.J. // J. Food Sci. 2016. V. 81. P. 494.
Moussa Z., Hmadeh M., Abiad M.G., Dib O.H., Patra D. // Food Chem. 2016. V. 212. P. 485.
Drakalska E., Momekova D., Manolova Y., Budurova D., Momekov G., Genova M., Antonov L., Lambov N., Rangelov S. // Int. J. Pharm. 2014. V. 472. P. 165–174.
Blokhin A.N., Razina A.B., Bursian A.E., Ten’kovtsev A.V. // Polymer Science B. 2021. V. 63. № 1. P. 52.
Blokhin A.N., Razina A.B., Tenkovtsev A.V. // Key Eng. Mater. 2021. V. 899. P. 300.
Ahmed M., Qadir M.A., Shafiq M.I., Muddassar M., Hameed A., Arshad M.N., Asiri A.M. // Acta Pharm. 2017. V. 67. P. 385.
Соколова Ю.Д., Челнакова П.Н., Коновалов Е.В. // Universum: химия и биология. 2016. № 12 (30).
Amirova A., Tobolina A., Kirila T., Blokhin A., Razina A., Tenkovtsev A., Filippov A. // Int. J. Polym. Anal. Charact. 2018. V. 23. P. 278.
Amirova A., Blokhin A., Razina A., Tenkovtsev A., Filippov A. // Mendeleev Commun. 2019. V. 29. P. 472.
Amirova A.I., Kirila T.U., Blokhin A.N., Razina A.B., Bursian A.E., Tenkovtsev A.V., Filippov A.P. // Mendeleev Commun. 2020. V. 30. P. 502.
Kirila T. Amirova, A., Blokhin A., Tenkovtsev A., Filippov A. // Polymers. 2021. V. 13. P. 2507.
Lebed A.S., Yefimova S.L., Guralchuk G.Ya., Sorokin A.V., Borovoy I.A., Malyukin Yu.V. // Biophysichny Vestnik. 2010. V. 24. P. 46.
Mareeswaran P.M., Babu E., Sathish V., Kim B., Woob S.I., Rajagopala S. // New J. Chem. 2014. V. 38. P. 1336.
Wang R., Yu Z. // Acta Phys.-Chim. Sin. 2007. V. 23. P. 1353.
Nafisi S., Adelzadeh M., Norouzi Z., Sarbolouki M.N. // DNA Cell Biol. 2009. V. 28. P. 201.
Mohammadi F., Bordbar A.K., Divsalar A., Mohammadi K., Saboury A.A. // Protein J. 2009. V. 28. P. 189.