Complexes of an Anionic Surfactant with Chitosan and Its Hydrophobic Derivatives As Disinfectants against SARS-CoV-2

A. V. Shibaev; Шибаев А. В.; A. S. Ospennikov; Оспенников А. С.; G. V. Kornilaeva; Корнилаева Г. В.; V. F. Larichev; Ларичев В. Ф.; I. T. Fedyakina; Федякина И. Т.; Lifeng Fu; Fu Lifeng; Zhuo Chen; Chen Zhuo; Yangyang Yang; Yang Yangyang; E. V. Karamov; Карамов Э. В.; A. S. Turgiev; Тургиев А. С.; Liping Duan; Duan Liping; Jun Liu; Liu Jun; O. E. Philippova; Филиппова О. Е.

doi:10.31857/S2308112023600114

Complexes of an Anionic Surfactant with Chitosan and Its Hydrophobic Derivatives As Disinfectants against SARS-CoV-2

Authors: Shibaev A.V.¹, Ospennikov A.S.¹, Kornilaeva G.V.², Larichev V.F.², Fedyakina I.T.², Fu L.³, Chen Z.⁴, Yang Y.⁴, Karamov E.V.²^,5, Turgiev A.S.²^,5, Duan L.⁶, Liu J.⁷, Philippova O.E.¹
Affiliations:
1. Physics Department, Moscow State University
2. Gamaleya National Research Center for Epidemiology and Microbiology of the Russian Ministry of Health
3. CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS)
4. Shanghai Key Laboratory of Chemical Biology, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology
5. National Medical Research Center of Phthisiopulmonology and Infectious Diseases of the Russian Ministry of Health
6. NHC Key Laboratory of Parasite and Vector Biology, WHO Collaborating Centre for Tropical Diseases, National Institute of Parasitic Diseases, Chinese Center for Disease Control and
7. NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC)
Issue: Vol 65, No 5 (2023)
Pages: 343-350
Section: МЕДИЦИНСКИЕ ПОЛИМЕРЫ
URL: https://journals.rcsi.science/2308-1120/article/view/233619
DOI: https://doi.org/10.31857/S2308112023600114
EDN: https://elibrary.ru/DCRAHG
ID: 233619

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Abstract

This work is aimed at the preparation of complexes of chitosan and hydrophobically modified (HM) chitosan with an anionic surfactant sodium dodecylbenzene sulfonate (SDBS), and at the study of the virucidal activity of the complexes and their components against SARS-CoV-2. It is shown that the introduction of a sufficient amount (4 mol%) of hydrophobic n-dodecyl side groups provides the activity of HM chitosan against SARS-CoV-2 at moderate concentrations, at which unmodified chitosan and chitosan containing a lower amount of hydrophobic groups do not show any activity. Complexes of HM chitosan with SDBS are prepared, which is proven by fluorescence spectroscopy and isothermal titration calorimetry. It is discovered that HM chitosan/SDBS complex is more active than the polymer without surfactant, and an increase of the amount of hydrophobic groups enhances the activity

Keywords

anionic disinfectants, SARS-CoV-2, chitosan, hydrophobic modification, polymer/surfactant, complexes

References

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