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Hydrogels Based on Interpolymer Complexes of Sodium Alginate and Synthetic Polyacids
- Authors: Volkova I.F.1, Grigoryan E.S.1, Shandryuk G.A.1, Gorshkova M.Y.1
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Affiliations:
- Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences
- Issue: Vol 65, No 1 (2023)
- Pages: 54-64
- Section: ПОЛИМЕРНЫЕ ГЕЛИ
- URL: https://journals.rcsi.science/2308-1120/article/view/135338
- DOI: https://doi.org/10.31857/S230811202370030X
- EDN: https://elibrary.ru/UYYESQ
- ID: 135338
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Abstract
Effect of the structure of synthetic polyacids on the formation and properties of their interpolymer complexes with sodium alginate is investigated. The hydrogels was shown to be predominantly formed via hydrogen bonds, with their type depending on the structure of polyacid and the amount of bound water. Study of the behavior of the hydrogels in water and phosphate-buffed saline with рН 7.2 demonstrates that the properties of the hydrogels are influenced by the ratio of components and the treatment temperature, in addition to the nature of polyacid. The possibility of using hydrogels as a basis for drug delivery systems is examined by the example of preparation lidocaine.
About the authors
I. F. Volkova
Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences
Email: mgor@ips.ac.ru
119991, Moscow, Russia
E. S. Grigoryan
Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences
Email: mgor@ips.ac.ru
119991, Moscow, Russia
G. A. Shandryuk
Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences
Email: mgor@ips.ac.ru
119991, Moscow, Russia
M. Yu. Gorshkova
Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences
Author for correspondence.
Email: mgor@ips.ac.ru
119991, Moscow, Russia
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