Obesity as a reflection of psycho-emotional disorders: focus on pharmacotherapy

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Obesity is a vivid example of a multifactorial disease. In its development, not only the discrepancy between the energy intake and its expenditure but also various neurohumoral mechanisms, as well as external socio-economic and psychosocial factors, play important roles. One of the frequent options for combining psychoemotional disorders with obesity is the development of certain types of eating disorders in a patient. In this regard, the actual problem is to find the optimal therapeutic and prophylactic strategy in the management of such patients.

The aim of the work is to analyze the literature data on the features of the pathogenetic mechanisms of the obesity development against the background of psychoemotional disorders that are realized through eating disorders, and to identify the possibilities of using sibutramine to carry out a pharmacological correction of these pathological conditions.

Materials and methods. In the process of selecting materials for writing a review article, the following databases were uses: PubMed, Scopus, Web of Science, Google Scholar, ScienceDirect, etc. The search carried out, was based on the publications for the period from 2009 to 2020. The following words and phrases were chosen as parameters for the literature selection: obesity, psycho-emotional disorders, eating disorders, sibutramine.

Results. This review summarizes the main pathogenetic aspects that unite both the development of psychoemotional and metabolic disorders. A modern classification of obesity, taking into account the latest domestic and international recommendations of professional communities, is given. Eating disorders are considered in detail, their socio-psychological and psychiatric classifications are given. The prospect of choosing a therapeutic and prophylactic strategy for managing such patients is assessed, depending on the presence of psycho-emotional and eating disorders.

Conclusion. Thus, the combined drug containing sibutramine and metformin registered in the Russian Federation is effective, safe and can be used in patients with alimentary obesity and eating disorders, taking into account contraindications.

Abbreviations: CNCD – chronic non-communicable diseases; RF – Russian Federation; WHO – World Health Organization; BMI – body mass index; WC – waist circumference; HC – hip circumference; CVD – cardiovascular diseases; NA – anorexia nervosa; BN – bulimia nervosa; PO – pathological overeating; GIT – gastrointestinal tract; AH – arterial hypertension; BP – blood pressure; DM2 – type 2 diabetes mellitus; CI – confidence interval.

作者简介

Veronika Shishkova

National Medical Research Center for Therapy and Preventive Medicine

编辑信件的主要联系方式.
Email: veronika-1306@mail.ru
ORCID iD: 0000-0002-1042-4275

Doctor of Sciences (Medicine), Head of the Department for the Prevention of Cognitive and Psychoemotional Disorder

俄罗斯联邦, Bld. 3, 10, Petroverigsky Ln., Moscow, 101000

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