INVESTIGATION FOR THE INFLUENCE OF DIFFERENT MAGNESIUM SULFATE DOSES ON THE CONTENT OF CALCIUM AND CHLORIDE IN BLOOD SERUM OF RATS OF BOTH GENDERS


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Abstract

We have conducted an investigation for the influence of different magnesium sulfate doses on the content of calcium and chloride in blood serum of rats of both genders. As the result of the study, we have established that peroral administration of magnesium sulfate at dose 1.7 g/kg leads to the significant decrease of chlorides content in blood serum of male rats, concerning the control group of animals, and at dose 5 g/kg to the decrease of concentration, chloride as well as calcium in rats of both genders.

About the authors

A. V Voronkov

Pyatigorsk Medical and Pharmaceutical Institute - branch of Volgograd State Medical University

Email: a.v.voronkov@pmedpharm.ru
Pyatigorsk, Russian Federation

A. Yu Terekhov

Pyatigorsk Medical and Pharmaceutical Institute - branch of Volgograd State Medical University

Email: tau200@yandex.ru
Pyatigorsk, Russian Federation

N. I Dyakova

Pyatigorsk Medical and Pharmaceutical Institute - branch of Volgograd State Medical University

Email: irochkadyakova@mail.ru
Pyatigorsk, Russian Federation

N. S Avramenko

Pyatigorsk Medical and Pharmaceutical Institute - branch of Volgograd State Medical University

Pyatigorsk, Russian Federation

D. I Pozdnyakov

Pyatigorsk Medical and Pharmaceutical Institute - branch of Volgograd State Medical University

Email: pozdniakow.dmitry@yandex.ru
Pyatigorsk, Russian Federation

S. A Kuleshova

Pyatigorsk Medical and Pharmaceutical Institute - branch of Volgograd State Medical University

Pyatigorsk, Russian Federation

References

  1. Creytens G. Le Lactulose dans le traitement de la constipation chronique et 1’abus des laxatives// Аrs Med. - 1980. - Vol. 35. - Р. 737-757.
  2. Hallmann F. Toxicity of commonly used laxatives // Med. Sci. Monit. 2000. Vol. 6(3).: Р. 618-628.
  3. Panesar P.S., Kumari S. Lactulose: production, purifi cation and potential application // Biotechnol. Adv. 2011. Vol. 29 (6): Р. 940-946158.
  4. Neims D.M., McNeill J., Giles T.R., Todd F. Incidence of laxativeсabuse in community and bulimic populations: a descriptive review // Int. J. Eat. Disord. 1990. Vol.17: Р. 211-228.
  5. Лузина Е.В. Безопасность использования слабительных средств // Российский медицинский журнал. - 2014. - №5. - С. 41-44.
  6. Руководство по проведению доклинических исследований лекарственных средств / Под ред. А.Н. Миронова. - М.: Гриф и К, 2012. - Ч. I. - 944 с.

Copyright (c) 2016 Voronkov A.V., Terekhov A.Y., Dyakova N.I., Avramenko N.S., Pozdnyakov D.I., Kuleshova S.A.

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This work is licensed under a Creative Commons Attribution 4.0 International License.
 

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