POSSIBILITIY OF SHORT-TERM STRESS INFLUENCES IMPLEMENTATION IN BIOLOGICALLY ACTIVE COMPOUNDS SCREENING
- Authors: Tarasov A.S1, Morkovin E.I1, Stepanova V.V1
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Affiliations:
- Volgograd State Medical University, Volgograd
- Issue: Vol 3, No 3 (2015)
- Pages: 66-68
- Section: Articles
- URL: https://journals.rcsi.science/2307-9266/article/view/111345
- ID: 111345
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Abstract
This work presents the analysis of phobic anxiety behavioral reactions connected with short-term stress influences. We have established that 15 minutes forced swimming reduces locomotory and exploratory activity of animals without any connection with physical exhaustion. Short-term isolation provokes the increase of irrational searching activity connected with spatial disorder and agitation. During this work we have formed an algorithm which allowed fast screening of anxiolytics and antidepressants.
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##article.viewOnOriginalSite##About the authors
A. S Tarasov
Volgograd State Medical University, Volgograd
Email: starostyn@rambler.ru
г. Волгоград
E. I Morkovin
Volgograd State Medical University, Volgograd
Email: e.i.morkovin@gmail.com
г. Волгоград
V. V Stepanova
Volgograd State Medical University, Volgograd
Email: lerivaphoto@gmail.com
г. Волгоград
References
- Методические рекомендации по доклиническому изучению транквилизирующего (анксиолитического) действия лекарственных средств / Т.А. Воронина, С.Б. Середенин, М.А. Яркова и др. // В кн.: Руководство по проведению доклинических исследований лекарственных средств. - М.: Гриф и К, 2012. - Ч. I. - 944 с.
- Тюренков, И.Н. Влияние фенибута, его солей и композиций с органическими кислотами на физическую работоспособность / И.Н. Тюренков, Е.В. Волотова, В.Н. Перфилова // Вестник Волгоградского государственного медицинского университета. - 2007. - № 1. - С. 65-67.
- Levels of anxiety and depression as predictors of mortality: the HUNT study / A. Mykletun, O. Bjerkeset, S. Overland et al. // Br. J. Psychiatry. - 2009. - Vol. 195(2). - P. 118-125.
