Atypical course of dengue fever with a symptom complex of acute hepatitis

Dengue fever, caused by an arbovirus of the Flavivirus genus, is a significant transmissible viral infection that poses a serious threat to public health. An analysis of imported cases reveals a clear correlation with international tourism to endemic regions.

This article presents a clinical case of an atypical dengue fever course characterized by the development of acute hepatitis in the absence of other typical clinical and laboratory manifestations of the disease, including skin rashes, leukopenia, thrombocytopenia, and coagulopathy. This phenomenon significantly complicated the diagnostic process and required a comprehensive approach to verifying the diagnosis, including differential diagnosis with a range of infectious and non-infectious diseases associated with liver damage. The relevance of this problem is attributable to the growing threat to public health associated with the expansion of dengue fever and the involvement of areas previously considered non-endemic in the epidemic. Of additional concern is the high risk of developing severe forms of the disease, including hemorrhagic ones, upon reinfection with a different serotype. The atypical clinical course of dengue fever emphasizes the need for a differential diagnosis with a thorough assessment of the epidemiological history, clinical manifestations, and laboratory parameters.