Characteristics of the combined course of pertussis and seasonal coronavirus infection in children

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Abstract

Objective: Evaluation of the characteristics of the concomitant course of pertussis and seasonal coronavirus infection in children.

Materials and methods. Data from 25 patients with pertussis and seasonal coronavirus infection hospitalized in the specialized department of the Infectious Diseases Clinical Hospital № 1 of the Department of Healthcare of the city of Moscow in 2023–2024 were analyzed. PCR and serological diagnostics (ELISA) were used to verify pertussis. Diagnosis of viral infections was based on PCR testing of nasopharyngeal mucus.

Results. Combination of pertussis with and seasonal coronavirus infection occurred predominantly in moderate form in 19 children (76.0 ± 8.5%), while severe forms were observed in only 6 patients (24.0 ± 8.5%). In nasopharyngeal mucus, among the seasonal coronavirus species, HCoV HKU1 was isolated from 8 patients with pertussis (32.0 ± 9.3%), HCoV-NL63 – from 11 (44.0 ± 9.9%), and HCoV-OC43 – from 6 (24.0 ± 8.5%). Studies have shown that the severity of pertussis, frequency, and nature of bronchopulmonary complications depended on the HCoV species.

Conclusion. The combination of pertussis and seasonal coronavirus infection among hospitalized patients was most often associated with HCoV-NL63. The clinical features of this mixed infection may be determined by the species of seasonal coronavirus. β-coronaviruses: HCoV-OC43 and HCoV-HKU1, had the most unfavorable effect on the course of pertussis.

About the authors

Olga P. Popova

Russian Medical Academy of Continuous Professional Education, Ministry of Health of the Russia; G.N. Gabrichevsky Moscow Research Institute of Microbiology and Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Author for correspondence.
Email: doctorpopova@yandex.ru
ORCID iD: 0000-0002-1772-5978

МD, Professor, Department of Pediatric Infectious Diseases, Leading Researcher, Department of Immunology

Russian Federation, Moscow; Moscow

Sergey V. Bunin

Infectious Diseases Clinical Hospital № 1, Department of Healthcare of the city of Moscow

Email: bunin_sergey72@mail.ru

Head, 3rd Pediatric Department

Russian Federation, Moscow

Svetlana V. Trushakova

N.F. Gamaleya National Research Center of Epidemiology and Microbiology, Ministry of Health of the Russia

Email: s.trushakova@gmail.com
ORCID iD: 0000-0002-9610-3041

Cand Biol. Sci., Senior Researcher, Laboratory of Influenza Etiology and Epidemiology

Russian Federation, Moscow

Yulia V. Shvetsova

Infectious Diseases Clinical Hospital № 1, Department of Healthcare of the city of Moscow

Email: juliashvetsova1983@gmail.ru
ORCID iD: 0009-0004-0151-7164

Pediatrician, 9th Pediatric Department of Infectious Diseases

Russian Federation, Moscow

Irina M. Fedorova

G.N. Gabrichevsky Moscow Research Institute of Microbiology and Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: 1vestnik-07@mail.ru
ORCID iD: 0000-0002-0335-2752

Cand Med. Sci., Leading Researcher, Laboratory for the Study of Cellular and Molecular Bases of Immunity

Russian Federation, Moscow

Svetlana I. Koteleva

G.N. Gabrichevsky Moscow Research Institute of Microbiology and Epidemiology, Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being

Email: felileo@yandex.ru
ORCID iD: 0000-0003-1878-2234

Cand Med. Sci., Leading Researcher, Laboratory for the Study of the Cellular and Molecular Bases of Immunity

Russian Federation, Moscow

Ksenia V. Zharikova

Infectious Diseases Clinical Hospital № 1, Department of Healthcare of the city of Moscow

Email: doctorzharikova@mail.ru
ORCID iD: 0009-0006-7317-4492

Pediatrician, 9th Pediatric Department of Infectious Diseases

Russian Federation, Moscow

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