Experience of independent collection of biological samples at the first stage of screening for HPV-associated diseases in HIV-infected women in Eastern Europe and Central Asia
- Authors: Popova A.A.1,2, Domonova E.A.1, Prilepskaya D.R.1, Romanyuk T.N.1, Shegai M.M.3, Rzaeva A.M.4, Babazade S.4, Gasich E.L.5, Lohinava V.P.6, Sergienko S.V.7, Toytukova M.M.8, Bekbolotov A.A.8, Zhaanbaeva Z.B.9, Narmatova E.B.10, Samarina A.V.11,12, Shamaeva N.S.12, Yokubov I.R.13, Mayer Y.I.14,15, Konareva I.G.15
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Affiliations:
- Central Research Institute of Epidemiology, Russian Federal Service for Surveillance on Consumer Rights Protection and Human Well-Being
- Russian Medical Academy of Continuous Professional Education, Ministry of Health of the Russia
- N.A. Semashko National Research Institute of Public Health, Ministry of Education and Science of the Russian Federation
- Republican AIDS Center, Ministry of Health of the Republic of Azerbaijan
- Republican Scientific and Practical Center for Epidemiology and Microbiology
- Republican Scientific and Practical Center for Radiation Medicine and Human Ecology
- Republican Center for Hygiene, Epidemiology, and Public Health
- Republican Center for Control of Blood-Borne Viral Hepatitis and Human Immunodeficiency Virus of the Kyrgyz Republic
- Bishkek City Center for Control of Blood-Borne Viral Hepatitis and HIV
- Osh Regional Center for Control of Blood-Borne Viral Hepatitis and Human Immunodeficiency Virus
- Pavlov First St. Petersburg State Medical University
- Center for the Prevention and Control of AIDS and Infectious Diseases
- Republican Center for the HIV/AIDS Prevention and Control, Ministry of Health and Social Protection of the Republic of Tajikistan
- Surgut State University
- Surgut District Clinical Center for Maternal and Child Health
- Issue: Vol 15, No 4 (2025)
- Pages: 46-53
- Section: Original Investigations
- URL: https://journals.rcsi.science/2226-6976/article/view/375458
- DOI: https://doi.org/10.18565/epidem.2025.15.4.46-53
- ID: 375458
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Abstract
In Eastern Europe and Central Asia (EECA), given the lack of widespread human papillomavirus (HPV) vaccination, timely screening is the mainstay of HPV-associated disease prevention in women. A progressive approach is the introduction of self-sampling for HPV testing, which maximizes screening coverage while reducing costs in this region.
Objective. Evaluation of the effectiveness of using an individual kit for self-sampling of vaginal and anal discharge during HPV testing at the first stage of screening for precancerous lesions of the cervix, vagina, and anal canal in HIV-infected women in EECA.
Materials and method. The study involved 1,200 women from five Eastern European Central Asian countries (the Russian Federation, the Republic of Azerbaijan, the Republic of Belarus, the Kyrgyz Republic, and the Republic of Tajikistan). Samples of cervical and anal swabs, vaginal mucosal secretions collected by medical personnel, and vaginal and anal mucosal secretions collected by patients themselves were analyzed. The ease of use of the individual sample collection kit was assessed using a questionnaire. Real-time PCR was used to detect HPV DNA.
Results. Data obtained from self-collection of biological material by patients were comparable to those obtained from collection by a medical professional. The questionnaire demonstrated that the sample collection kit was easy and convenient to use, and the instructions were clear. An assessment of personal preferences for choosing the method of sample collection revealed that only 11% of HIV-positive respondents would prefer a traditional doctor’s visit in the future.
Conclusion. No significant difference was found between the methods of collecting biological material for HPV testing (p > 0.05). Using self-collection of biological material will significantly increase the coverage of HIV-infected women for screening for precancerous lesions of the cervix, vagina, and anal canal.
About the authors
Anna A. Popova
Central Research Institute of Epidemiology, Russian Federal Service for Surveillance on Consumer Rights Protection and Human Well-Being; Russian Medical Academy of Continuous Professional Education, Ministry of Health of the Russia
Author for correspondence.
Email: popova@cmd.su
ORCID iD: 0000-0001-9484-5917
Cand. Med. Sci., Senior Researcher, Associate Professor, Department of Infectious Diseases
Russian Federation, Moscow; MoscowElvira A. Domonova
Central Research Institute of Epidemiology, Russian Federal Service for Surveillance on Consumer Rights Protection and Human Well-Being
Email: еlvira.domonova@pcr.ms
ORCID iD: 0000-0001-8262-3938
Cand. Boil. Sci., Head, Laboratory of Molecular Diagnostics and Epidemiology of Opportunistic Infections
Russian Federation, MoscowDiana R. Prilepskaya
Central Research Institute of Epidemiology, Russian Federal Service for Surveillance on Consumer Rights Protection and Human Well-Being
Email: prilepskaya.d@cmd.su
ORCID iD: 0000-0002-9305-4299
Researcher
Russian Federation, MoscowTatyana N. Romanyuk
Central Research Institute of Epidemiology, Russian Federal Service for Surveillance on Consumer Rights Protection and Human Well-Being
Email: tatiana.romaniuk@pcr.ms
ORCID iD: 0009-0006-1952-907X
Biologist
Russian Federation, MoscowMarina M. Shegai
N.A. Semashko National Research Institute of Public Health, Ministry of Education and Science of the Russian Federation
Email: mshegai@yandex.ru
ORCID iD: 0000-0003-4054-1998
МD., Leading Researcher, Department of Public Health Research, Advisor to the Director
Russian Federation, MoscowAdela M. Rzaeva
Republican AIDS Center, Ministry of Health of the Republic of Azerbaijan
Email: rzayeva.adela@gmail.com
ORCID iD: 0000-0003-1697-5630
Head, Admission Department
Azerbaijan, BakuSabina Babazade
Republican AIDS Center, Ministry of Health of the Republic of Azerbaijan
Email: sabina.babazade_aids@mail.ru
ORCID iD: 0009-0000-8470-2410
Deputy Director
Azerbaijan, BakuElena L. Gasich
Republican Scientific and Practical Center for Epidemiology and Microbiology
Email: elena.gasich@gmail.com
ORCID iD: 0000-0002-3662-3045
ВD, Associate Professor, Head, Laboratory for the Diagnosis of HIV and Co-infections
Belarus, MinskVolha P. Lohinava
Republican Scientific and Practical Center for Radiation Medicine and Human Ecology
Email: gal301@mail.ru
ORCID iD: 0000-0001-7189-3799
Doctor of Clinical Laboratory Diagnostics, Laboratory of Cellular Technologies
Belarus, GomelSvetlana V. Sergienko
Republican Center for Hygiene, Epidemiology, and Public Health
Email: svetlana-s.v@mail.ru
ORCID iD: 0009-0009-2600-9760
Epidemiologist, Department of HIV Infection Prevention
Belarus, MinskMolmol M. Toytukova
Republican Center for Control of Blood-Borne Viral Hepatitis and Human Immunodeficiency Virus of the Kyrgyz Republic
Email: molmol7777@mail.ru
ORCID iD: 0009-0004-9580-4200
Obstetrician-Gynecologist
Kyrgyzstan, BishkekAibek A. Bekbolotov
Republican Center for Control of Blood-Borne Viral Hepatitis and Human Immunodeficiency Virus of the Kyrgyz Republic
Email: aibek_0001@mail.ru
deputy director
Kyrgyzstan, BishkekZhanyl B. Zhaanbaeva
Bishkek City Center for Control of Blood-Borne Viral Hepatitis and HIV
Email: doctorjaanbaeva@yandex.ru
Obstetrician-Gynaecologist
Kyrgyzstan, BishkekElmira B. Narmatova
Osh Regional Center for Control of Blood-Borne Viral Hepatitis and Human Immunodeficiency Virus
Email: elmira.narmatova@yandex.ru
Director
Kyrgyzstan, OshAnna V. Samarina
Pavlov First St. Petersburg State Medical University; Center for the Prevention and Control of AIDS and Infectious Diseases
Email: avsamarina@mail.ru
ORCID iD: 0000-0003-1438-2399
МD, Associate Professor, Professor, Department of Socially Significant Infections and Phthisiopulmonology, Head, Department of Maternity and Childhood
Russian Federation, St. Petersburg; St. PetersburgNatalia S. Shamaeva
Center for the Prevention and Control of AIDS and Infectious Diseases
Email: nataljaklokova@mail.ru
ORCID iD: 0009-0005-0565-1464
Obstetrician-Gynaecologist, Department of Motherhood and Childhood
Russian Federation, St. PetersburgIzzatullo R. Yokubov
Republican Center for the HIV/AIDS Prevention and Control, Ministry of Health and Social Protection of the Republic of Tajikistan
Email: yavan.ses@mail.ru
ORCID iD: 0009-0007-9245-3515
Doctor of the Highest Qualification Category, Honored Worker of Health Care of the Republic of Tajikistan, Head, Monitoring and Evaluation Department
Tajikistan, DushanbeYuliya I. Mayer
Surgut State University; Surgut District Clinical Center for Maternal and Child Health
Email: calm332@mail.ru
ORCID iD: 0009-0005-5256-4961
Cand. Med. Sci., Associate Professor Department of Obstetrics, Gynecology and Perinatology, Obstetrician-Gynecologist
Russian Federation, Surgut; SurgutIrina G. Konareva
Surgut District Clinical Center for Maternal and Child Health
Email: i.konareva@bk.ru
Obstetrician-Gynecologist, Head, Consultative and Diagnostic Department
Russian Federation, SurgutReferences
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