DEVELOPMENT OF A BIOLOGICALLY ACTIVE NANOSYSTEM BASED ON RIBOFLAVIN, A MICROELEMENT OF COPPER AND L-LYSINE AMINO ACID
- Authors: Blinov A.V.1, Golik A.B.1, Gvozdenko A.A.1, Kastarnova E.S.2, Orobets V.A.2, Yakovenko A.A.1, Bakholdina T.N.1
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Affiliations:
- North-Caucasian Federal University
- Stavropol State Agrarian University
- Issue: No 15 (2023)
- Pages: 930-939
- Section: Nanochemistry
- URL: https://journals.rcsi.science/2226-4442/article/view/378524
- DOI: https://doi.org/10.26456/pcascnn/2023.15.930
- EDN: https://elibrary.ru/QKHWHX
- ID: 378524
Cite item
Full Text
Abstract
А biologically active nanosystem based on riboflavin, copper microelement and the amino acid lysine copper lysinatoriboflavinate has been developed. The obtained sample of the biologically active additive was studied by a complex of modern methods of analysis, namely: spectrophotometry, scanning electron microscopy, spectrophotoluminescence spectroscopy. In addition, computer quantum chemical modeling was carried out. It has been established that the most energetically favorable model of a biologically active nanosystem based on riboflavin, a trace element of copper and lysine is a model in which riboflavin is bound to the copper ion through the enol oxygen at C 2 and the neighboring nitrogen heteroatom N 3, and lysine is bound to the copper ion through the carboxyl and amino groups in α position. As a result of the analysis of micrographs of a biologically active nanosystem based on riboflavin, copper microelement and lysine amino acid, it was found that the particles have an acicular structure, the width of individual crystals is from 100 to 300 nm, and the length reaches several microns. The energy-dispersive X-ray spectra of a biologically active nanosystem based on riboflavin, the microelement copper, and the amino acid lysine coincide with the theoretical concepts of the structure of the elements under consideration. The analysis did not show the presence of impurity compounds, which may allow us to judge the high purity of the developed compound.
About the authors
Andrey V. Blinov
North-Caucasian Federal UniversityStavropol, Russia
Aleksey B. Golik
North-Caucasian Federal University
Email: abgolik@ncfu.RUS
Stavropol, Russia
Aleksey A. Gvozdenko
North-Caucasian Federal UniversityStavropol, Russia
Elena S. Kastarnova
Stavropol State Agrarian UniversityStavropol, Russia
Vladimir A. Orobets
Stavropol State Agrarian UniversityStavropol, Russia
Andrey A. Yakovenko
North-Caucasian Federal UniversityStavropol, Russia
Tamara N. Bakholdina
North-Caucasian Federal UniversityStavropol, Russia
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