Formation of hybrid carriers based on albumin and polyoxometalate for targeted drug delivery

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Abstract

The use of proteins to create the targeted drug delivery systems is a promising approach in medicine and has many advantages. The formation of hybrid drug carriers based on proteins and polyoxometalates has a number of additional benefits. Polyoxometalates are able to bind both proteins and molecules of certain drugs to obtain water-soluble products without the use of toxic reagents and organic solvents. The regulation of the experimental conditions allows to control the size of the particles formed in solution. The gradual destruction of polyoxometalate { Mo72Fe30 } at blood pH provides a pH -dependent mechanism for drug release from the carrier structure. In our research, we obtained bovine serum albumin associated with coordination complexes { Mo72Fe30 }-doxorubicin and { Mo72Fe30 }-tetracycline in aqueous solution. A decrease in the rate of the drug release in a phosphate buffer solution at pH 7.4 (blood pH ) from the obtained materials compared to systems not containing albumin was observed. The data obtained in this study shed light on the formation patterns of multicomponent supramolecular systems, consisting of polyoxometalates, proteins, and drugs. The results indicate the possibility of creating hybrid carriers for targeted drug delivery based on polyoxometalates and albumin using non-covalent binding.

About the authors

Margarita O. Tonkushina

Ural Federal University

Ph. D., Senior Researcher, Department of Chemical Materials Science in Scientific Research Institute of Physics and Applied Mathematics

Ilya D. Gagarin

Ural Federal University

Ph. D., Junior Researcher, Department of Chemical Materials Science in Scientific Research Institute of Physics and Applied Mathematics

Barah T.M.A. Sharadgah

Ural Federal University

2nd postgraduate student, Department of Medical Biochemistry and Biophysics

Vitaliy R. Gavrilyuk

Ural Federal University

4th year student, Department of Fundamental and Applied Physics

Konstantin A. Piunov

Ural Federal University

4th year student, Department of Fundamental and Applied Physics

Alexander A. Ostroushko

Ural Federal University

Email: alexander.ostroushko@urfu.ru
Dr. Sc., Professor, Head of Department of Chemical Materials Science in Scientific Research Institute of Physics and Applied Mathematics

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