Pharmacogenetics of new oral anticoagulants
- 作者: Azimova B.1,2, Nikolayev K.2,3, Vorobyov A.1,2, Urvantseva I.1,2
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隶属关系:
- District Cardiological Dispensary Center for Diagnostics and Cardiovascular Surgery
- Surgut State University
- Research Institute of Therapy and Preventive Medicine – Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Branch of RAS
- 期: 卷 13, 编号 3 (2022)
- 页面: 162-167
- 栏目: Reviews
- URL: https://journals.rcsi.science/2221-7185/article/view/134173
- DOI: https://doi.org/10.17816/CS107195
- ID: 134173
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The review presents modern studies the effect of genetic polymorphisms on the efficienty and safety of therapy with new oral anticoagulants. Hepatic carboxylesterase encoded by the CES1 gene and P-glycoprotein encoded by the ABCB1 gene affect dabigatran pharmacokinetics. The role of glucuronidation enzymes (UGT2B15, UGT1A9, UGT2B7) involved in active dabigatran metabolism is poorly understood. An increase in the peak apixaban concentration was noted in patients with the rs4148738 polymorphism of the ABCB1 gene. Polymorphisms rs776746 and rs77674 of the CYP3A5 gene affect concentration of apixaban in Asian patients and thus increased the bleeding risk. The effect SULT1A1 sulfotransferase on the metabolism of apixaban has yet to be studied. The BCRP protein encoded by the ABCG2 gene is a poorly studied but promising direction for the pharmacokinetics of apixaban. ABCB1 and CYP3A4 of the cytochrome P450 system affect the rivaroxaban metabolism, however, the number of studies devoted to examining the effect of polymorphisms of these genes on the rivaroxaban pharmacokinetics limited. Thus, large studies are needed to clarify the clinical relevance of genotyping in target patients taking new oral anticoagulants.
作者简介
Bella Azimova
District Cardiological Dispensary Center for Diagnostics and Cardiovascular Surgery; Surgut State University
Email: bella_azimova_surgut@mail.ru
ORCID iD: 0000-0003-3190-3782
graduate student
俄罗斯联邦, 1 Lenin Ave., 628403, Surgut; SurgutKonstsantin Nikolayev
Surgut State University; Research Institute of Therapy and Preventive Medicine – Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Branch of RAS
Email: nikolaevky@yandex.ru
ORCID iD: 0000-0003-4601-6203
SPIN 代码: 6638-2290
MD, D. Sci. (Med.), Prof., laboratory head
俄罗斯联邦, 1, Lenina Ave., Surgut, 628400; NovosibirskAnton Vorobyov
District Cardiological Dispensary Center for Diagnostics and Cardiovascular Surgery; Surgut State University
Email: a.s.vorobyov@google.com
ORCID iD: 0000-0001-7014-2096
SPIN 代码: 1756-6168
MD, Cand. Sci. (Med.), Assoc. Prof., leading reseacher
俄罗斯联邦, 1, Lenina Ave., Surgut, 628400; SurgutIrina Urvantseva
District Cardiological Dispensary Center for Diagnostics and Cardiovascular Surgery; Surgut State University
编辑信件的主要联系方式.
Email: priem@cardioc.ru
ORCID iD: 0000-0002-5545-9826
SPIN 代码: 3495-6523
MD, Cand. Sci. (Med.), department head, chief physician
俄罗斯联邦, 1, Lenina Ave., Surgut, 628400; Surgut参考
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