Peripheral blood leukocyte telomere length as a possible prognostic marker for the development of atrial fibrillation
- Authors: Nikulina S.Y.1, Shihkova K.Y.1, Shulman V.A.1, Chernova A.A.1, Maksimov V.N.2
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Affiliations:
- Voino-Yasenetsky Krasnoyarsk State Medical University
- Institute of Internal and Preventive Medicine – a branch of the Federal Research Center Institute of Cytology and Genetics
- Issue: Vol 11, No 2 (2020)
- Pages: 50-54
- Section: Reviews
- URL: https://journals.rcsi.science/2221-7185/article/view/46032
- DOI: https://doi.org/10.26442/22217185.2020.2.200227
- ID: 46032
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Abstract
Atrial fibrillation is one of the most common heart rhythm disorders. The most prominent risk factor for atrial fibrillation is advanced age. Population ageing contributes to an increase in both the prevalence of this pathology and socio-economic burden of the disease for society in general and the patient in particular. Adequate therapy and prevention of atrial fibrillation requires the search for novel prognostic risk markers for disease development, progression, and patients’ response to therapy. One of these markers is the length of telomeres – structures at the ends of chromosomes that protect them from degradation during cell division. The article provides an overview of world studies, both confirming and disproving the role of leukocyte telomere length in atrial fibrillation development.
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##article.viewOnOriginalSite##About the authors
Svetlana Yu. Nikulina
Voino-Yasenetsky Krasnoyarsk State Medical University
Author for correspondence.
Email: nicoulina@mail.ru
D. Sci. (Med.), Prof., Voino-Yasenetsky Krasnoyarsk State Medical University
Russian Federation, KrasnoyarskKsenya Yu. Shihkova
Voino-Yasenetsky Krasnoyarsk State Medical University
Email: tadtaeva93@mail.ru
Graduate Student, Voino-Yasenetsky Krasnoyarsk State Medical University
Russian Federation, KrasnoyarskVladimir A. Shulman
Voino-Yasenetsky Krasnoyarsk State Medical University
Email: shulman36@mail.ru
Prof., Voino-Yasenetsky Krasnoyarsk State Medical University
Russian Federation, KrasnoyarskAnna A. Chernova
Voino-Yasenetsky Krasnoyarsk State Medical University
Email: anechkachernova@yandex.ru
D. Sci. (Med.), Prof., Voino-Yasenetsky Krasnoyarsk State Medical University
Russian Federation, KrasnoyarskVladimir N. Maksimov
Institute of Internal and Preventive Medicine – a branch of the Federal Research Center Institute of Cytology and Genetics
Email: medik11@mail.ru
D. Sci. (Med.), Prof., Institute of Internal and Preventive Medicine – a branch of the Federal Research Center Institute of Cytology and Genetics
Russian Federation, NovosibirskReferences
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